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Method for producing fluorinated alkane, method for separating and recovering amidine base, and method for using recovered amidine base
US10392325B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10392325-B2 |
| Application number | US-201615561456-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 29, 2016 |
| Priority date | Mar 31, 2015 |
| Publication date | Aug 27, 2019 |
| Grant date | Aug 27, 2019 |
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- Title
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Abstract
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The present invention provides: a method for producing a fluorinated alkane represented by the formula (2): R 2 —F, wherein an alcohol having 3 to 5 carbon atoms is fluorinated by a fluorinating agent represented by the formula (1): R 1 SO 2 F in the absence of a solvent, and in the presence of an amidine base. In the formula, R 1 represents a methyl group, an ethyl group or an aromatic group, R 2 represents an alkyl group having 3 to 5 carbon atoms, and n is 0 or 2.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for producing a fluorinated alkane represented by the formula (2): R 2 —F (R 2 represents an alkyl group having 3 to 5 carbon atoms), wherein an alcohol having 3 to 5 carbon atoms is fluorinated by a fluorinating agent represented by the formula (1): R 1 SO 2 F (R 1 represents a methyl group, an ethyl group or an aromatic group) in the absence of a solvent, and in the presence of an amidine base, and wherein the base is the amidine base represented by the following formula (4): (in the formula, n is 0 or 2). 2. The method for producing a fluorinated alkane according to claim 1 , wherein the reaction is performed by adding the fluorinating agent to the mixture of the alcohol having 3 to 5 carbon atoms and the base at 60° C. to 150° C. 3. The method for producing a fluorinated alkane according to claim 1 , wherein the fluorinating agent is methanesulfonyl fluoride. 4. The method for producing a fluorinated alkane according to claim 1 , wherein the fluorinated alkane is 2-fluorobutane. 5. A method for producing a fluorinated alkane represented by the formula (2): R 2 —F (R 2 represents an alkyl group having 3 to 5 carbon atoms), wherein an alcohol having 3 to 5 carbon atoms is fluorinated by a fluorinating agent represented by the formula (1): R 1 SO 2 F (R 1 represents a methyl group, an ethyl group or an aromatic group) in the absence of a solvent, and in the presence of an amidine base, and wherein the base is 1,8-diazabicyclo[5.4.0]undec-7-ene. 6. The method for producing a fluorinated alkane according to claim 5 , wherein the reaction is performed by adding the fluorinating agent to the mixture of the alcohol having 3 to 5 carbon atoms and the base at 60° C. to 150° C. 7. The method for producing a fluorinated alkane according to claim 5 , wherein the fluorinating agent is methanesulfonyl fluoride. 8. The method for producing a fluorinated alkane according to claim 5 , wherein the fluorinated alkane is 2-fluorobutane.
Assignees
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Classifications
containing fluorine · CPC title
- C07D471/04Primary
Ortho-condensed systems · CPC title
- C07C17/16Primary
of hydroxyl groups · CPC title
Azeotropic distillation · CPC title
Vacuum distillation (B01D3/12 takes precedence) · CPC title
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- What does patent US10392325B2 cover?
- The present invention provides: a method for producing a fluorinated alkane represented by the formula (2): R 2 —F, wherein an alcohol having 3 to 5 carbon atoms is fluorinated by a fluorinating agent represented by the formula (1): R 1 SO 2 F in the absence of a solvent, and in the presence of an amidine base. In the formula, R 1 represents a methyl group, an ethyl group or an aromatic group,…
- Who is the assignee on this patent?
- Kanto Denka Kogyo Kk, Zeon Corp
- What technology area does this patent fall under?
- Primary CPC classification C07D471/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 27 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).