Material non-adhesive to biological substance, curable composition, and artificial organ and medical instrument using same

Patent metadata

Field	Value
Publication number	US-10385151-B2
Application number	US-201715581703-A
Country	US
Kind code	B2
Filing date	Apr 28, 2017
Priority date	Oct 29, 2014
Publication date	Aug 20, 2019
Grant date	Aug 20, 2019

Abstract

A material non-adhesive to a biological substance containing: a polymer compound (A) which includes a repeating unit derived from a sulfobetaine monomer represented by Formula (I) or (II).

In the formulae, R 1 represents a methyl group, an ethyl group, an n-propyl group, or an isopropyl group, a plurality of R 1 's may be the same as or different from each other.
R 2 represents a hydrogen atom or a methyl group. n represents an integer of 2 to 4. L represents a linear or branched alkylene group having 3 or 4 carbon atoms.

First claim

What is claimed is:

1. A material non-adhesive to a biological substance containing:
a polymer compound (A) which includes a repeating unit derived from a sulfobetaine monomer represented by Formula (II), and which has a cross-linked structure,

in the formulae, R 1 represents a methyl group, an ethyl group, an n-propyl group, or an isopropyl group, and a plurality of R 1 's may be the same as or different from each other,
R 2 represents a hydrogen atom or a methyl group,
n represents an integer of 2 to 4, and
L represents a linear or branched alkylene group having 3 or 4 carbon atoms.

2. The material non-adhesive to a biological substance according to claim 1 ,
wherein the monomer represented by Formula (II) is a monomer represented by the following Formula (II-1):

3. The material non-adhesive to a biological substance according to claim 1 ,
wherein the polymer compound (A) includes a repeating unit derived from a copolymerizable monomer having an ethylenically unsaturated group, that can be copolymerized with the sulfobetaine monomer.

4. The material non-adhesive to a biological substance according to claim 1 ,
wherein the content of the repeating unit derived from the sulfobetaine monomer in the polymer compound (A) is in a range of 5% to 90%, on a mass basis.

5. The material non-adhesive to a biological substance according to claim 1 ,
wherein the biological substance is a cell or protein.

6. The material non-adhesive to a biological substance according to claim 1 ,
wherein a C Log P value of the sulfobetaine monomer is −20 or greater and less than −7.2.

7. The material non-adhesive to a biological substance according to claim 1 ,
wherein the cross-linked structure is a structure derived from at least one cross-linking agent selected from the following formulae (III) to (VII):

8. An artificial organ comprising:
the material non-adhesive to a biological substance according to claim 1 in at least a portion thereof.

9. A medical instrument comprising:
the material non-adhesive to a biological substance according to claim 1 in at least a portion thereof.

Assignees

• Fujifilm Corp

Inventors

• Fukagawa Kiyotaka

Classifications

• C08F220/606

  and containing other heteroatoms · CPC title

• A61L27/34

  Macromolecular materials · CPC title

• C08F228/02

  by a bond to sulfur · CPC title

• C08F20/60

  containing nitrogen in addition to the carbonamido nitrogen · CPC title

• A61L31/00

  Materials for other surgical articles {, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices (shape or structure of stent-grafts A61F2/07, of stents A61F2/82, of surgical gloves A61B42/00, of surgical drapes A61B46/00, of occluding devices A61B17/12022)} · CPC title