Methods of using select Schiff base compounds for chemical agent detoxification

Patent metadata

Field	Value
Publication number	US-10384090-B2
Application number	US-201815878573-A
Country	US
Kind code	B2
Filing date	Jan 24, 2018
Priority date	Sep 18, 2013
Publication date	Aug 20, 2019
Grant date	Aug 20, 2019

Abstract

A method of using select Schiff base compounds for chemical agent detoxification. The method including applying a compound to the contaminated substrate. The compound includes an imine having at least one Schiff base nitrogen and an alkyl substituent or an aryl substituent having an electron acceptor. The at least one Schiff base nitrogen is spaced away from the electron acceptor by a distance ranging from about 200 pm to about 1000 pm. The substrate and the compound are dried. The at least one Schiff base nitrogen of the compound promotes a nucleophilic attack on an electrophilic site of the toxic chemical agent.

First claim

What is claimed is:

1. A method of detoxifying a substrate contaminated with a toxic chemical agent, the method comprising:
applying a composition to the contaminated substrate, the composition comprising 8-hydroxyquinoline or 1,2-benzisothiazol-3(2H)-one; and
drying the substrate with the composition.

2. The method of 1 , wherein the toxic chemical agent is a nerve chemical warfare agent or a blister chemical warfare agent.

3. The method of claim 1 , wherein drying the substrate with the composition includes applying an electromagnetic radiation, applying irradiative heat, changing pH, or combinations thereof.

4. The method of claim 1 , wherein a quantity of the composition does not exceed 20 wt. %.

5. The method of claim 1 , wherein applying the composition further comprises:
cross-linking the composition to the substrate with a cross-linking agent that selected from the group consisting of a siloxane, an acrylate, and epoxide, and combinations thereof.

6. A method of preparing a detoxifying substrate, the method comprising:
selecting a first composition based on a first expected toxic chemical agent exposure, the first composition comprising 8-hydroxyquinoline or 1,2-benzisothiazol-3(2H)-one;
applying a quantity of the first selected composition to the substrate; and
optionally drying the substrate.

7. The method of claim 6 , further comprising:
selecting a second composition based on a second expected chemical agent exposure, the second composition comprising 8-hydroxyquinoline or 1,2-benzisothiazol-3(2H)-one;
applying a quantity of the second selected composition to the substrate; and
optionally drying the substrate.

8. The method of claim 7 , wherein a combined quantity of the first composition and the second composition does not exceed 20 wt. %.

9. The method of claim 6 , wherein drying the substrate includes applying an electromagnetic radiation, applying irradiative heat, changing pH, or combinations thereof.

10. A method of pretreating a substrate to resist toxic chemical agent contamination, the method comprising:
applying a composition to the substrate, the composition comprising 8-hydroxyquinoline or 1,2-benzisothiazol-3(2H)-one;
drying the substrate with the composition; and
exposing the pretreated substrate to a toxic chemical agent.

11. The method of 10 , wherein the toxic chemical agent is a nerve chemical warfare agent or a blister chemical warfare agent.

12. The method of claim 10 , wherein drying the substrate with the composition includes applying an electromagnetic radiation, applying irradiative heat, changing pH, or combinations thereof.

13. The method of claim 10 , wherein a quantity of the composition does not exceed 20 wt. %.

14. The method of claim 10 , wherein applying the composition further comprises:
cross-linking the composition to the substrate with a cross-linking agent that selected from the group consisting of a siloxane, an acrylate, and epoxide, and combinations thereof.

Assignees

• Government Of The Us Secretary Of The Air Force
• Us Air Force

Inventors

• Owens Jeffery Ray
• Salter Wallace Bruce
• Simpson Katherine Moss

Classifications

• D06M13/355

  having six-membered heterocyclic rings · CPC title

• D06M13/335

  having an amino group bound to a carbon atom of a six-membered aromatic ring · CPC title

• A62D3/36 Primary

  Detoxification by using acid or alkaline reagents · CPC title

• D06M13/272

  Unsaturated compounds containing sulfur atoms · CPC title

• A62D2101/26

  containing nitrogen or phosphorus · CPC title