Respiratory gating system for patient using natural breathing method during radiation therapy, and method for emitting radiation thereby

Patent metadata

Field	Value
Publication number	US-10384081-B2
Application number	US-201415304529-A
Country	US
Kind code	B2
Filing date	Jul 1, 2014
Priority date	Apr 16, 2014
Publication date	Aug 20, 2019
Grant date	Aug 20, 2019

Abstract

A respiratory gating system is disclosed that varies the orientation of a radiation emitting device according to a patient's natural breathing. A breathing respirator is provided that allows the patient's respiration amount to be measured. External markers are adhered to triangulation points around a radiation target region, such as a heart, of the patient. An image diagnosis device images the target region. A computed tomography device reveals movements of the target region caused by the respiration. Triangulations and polynomial approximations are used to estimate the trajectory of the target region in real time. Position coordinates derived from the estimated trajectory are transmitted to the radiation emitting device. The system increases the accuracy and stability of the entire radiation therapy result.

First claim

The invention claimed is:

1. A respiratory gating system for a patient using a natural breathing method, the system allowing radiation to be emitted by orienting to a position which varies according to a patient's breathing during radiation therapy of a target region of the patient on which treatment is to be carried out, the system comprising:
a breathing respirator configured to be placed over the patient's nasal cavity and mouth for allowing the patient's respiration amount to be measured;
a field programmable gate array (FPGA) that receives pressure data from the breathing respirator, determines a depth and amount of respiration, and generates a regular or irregular breathing pattern of the patient;
external markers to be respectively adhered to triangulation points in an area surrounding the target region;
an image device for imaging the target region by photographing the target region;
a non-transitory computer-readable storage media having instructions stored thereon that, when executed by a processor, causes the processor to perform
(a) triangulating an XY coordinate of the target region with coordinates of the external markers to estimate a position of the target region,
(b) repeating the triangulation as the patient breathes to determine a trajectory along which the target region is moving,
(c) generating a polynomial approximation of the trajectory, and
(d) generating position coordinates of the target region derived from the polynomial approximation; and

radiation therapy equipment that is configured to receive the position coordinates of the target region generated by the computer and adjust an on/off time of radiation based on a classification of the patient's breathing pattern.

2. The system of claim 1 , wherein the image device is a computed tomography (CT) device, fluoroscopy or magnetic resonance (MR) imaging device.

3. A method for emitting radiation to a target region of a patient on which treatment is to be carried out by a respiratory gating system allowing radiation to be emitted by orienting to a position, which varies according to a patient's breathing, the method comprising:
collecting pressure data from the patient using a breathing respirator positioned over a nasal cavity and a mouth of the patient;
adhering external markers to triangulation points outside the patient's body in an area surrounding the target region;
imaging a changing position of the target region due to respiration;
measuring the change in position, based on images of the external markers, of the target region;
triangulating an XY coordinate of the target region with coordinates of the external markers to estimate a position of the target region, and repeating the triangulation as the patient breathes to determine a trajectory along which the target region is moving;
generating a polynomial approximation of the trajectory;
transmitting the position coordinates of the target region, derived from the polynomial approximation, to radiation therapy equipment to emit radiation to the target region so that the radiation therapy equipment can more accurately track the target region as the patient breathes;
processing the pressure data, using a field programmable gate array (FPGA), to determine a depth and an amount of respiration;
classifying the patient's breathing pattern as a regular or irregular breathing pattern based on the determined depth and amount of respiration; and
adjusting an on/off time of radiation based on the patient's breathing pattern classification.

Assignees

• Catholic Univ Korea Ind Academic Cooperation Foundation

Inventors

• Jung Joo Young
• Yoon Do Kun
• Suh Tae Suk

Classifications

• A61B6/03

  Computed tomography [CT] · CPC title

• A61B5/0071

  by measuring fluorescence emission · CPC title

• A61B2017/00699

  correcting for movement caused by respiration, e.g. by triggering · CPC title

• A61N5/1068

  Gating the beam as a function of a physiological signal · CPC title

• A61B5/113

  occurring during breathing · CPC title