Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods

Patent metadata

Field	Value
Publication number	US-10383754-B2
Application number	US-201314100218-A
Country	US
Kind code	B2
Filing date	Dec 9, 2013
Priority date	May 26, 2010
Publication date	Aug 20, 2019
Grant date	Aug 20, 2019

Abstract

Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.

First claim

We claim:

1. A method of inducing satiety in a patient, the method comprising:
(a) folding a portion of the patient's intestine to create a folded portion, wherein the folded portion of the intestine extends transversely from adjacent sections of the intestine, and wherein the act of folding maintains the intestinal lumen in the folded portion of the intestine;
(b) forming an opening in the folded portion of the intestine to provide access to the inside of the intestinal lumen in the folded portion of the intestine;
(c) implanting a therapeutic device inside the intestinal lumen in the folded portion of the intestine;
(d) sealing the opening in the folded portion of the intestine to restrict access to the inside of the intestinal lumen in the folded portion of the intestine; and
(e) securing the therapeutic device inside the intestinal lumen in the folded portion of the intestine.

2. The method of claim 1 , wherein the method is performed laparoscopically.

3. The method of claim 1 , wherein the folded portion comprises overlapping sections of the intestine.

4. The method of claim 1 , wherein the act of implanting the therapeutic device comprises inserting the therapeutic device through the formed opening.

5. The method of claim 1 , further comprising inserting a stapler through the formed opening.

6. The method of claim 5 , further comprising actuating the stapler to secure the configuration of the folded portion.

7. The method of claim 1 , further comprising securing the configuration of the folded portion.

8. The method of claim 7 , wherein the act of securing the configuration of the folded portion comprises actuating a stapler.

9. The method of claim 1 , wherein the therapeutic device is configured to administer a therapeutic substance through a drip.

10. The method of claim 9 , wherein the therapeutic substance is configured to initiate an intestinal braking effect in the patient.

11. The method of claim 1 , wherein the therapeutic device is configured to administer linoleic acid.

12. The method of claim 1 , wherein the therapeutic device comprises a catheter.

13. The method of claim 12 , wherein the act of implanting the therapeutic device comprises positioning the catheter in a section of the intestine.

14. The method of claim 1 , wherein the act of securing the therapeutic device comprises applying an external ring clamp.

15. The method of claim 14 , wherein the act of applying the external ring clamp comprises positioning the external ring clamp between the therapeutic device and adjacent sections of the intestine.

16. A method of inducing satiety in a patient, the method comprising:
(a) bending a portion of the patient's intestine to create a bent portion, wherein the act of bending maintains the intestinal lumen in the bent portion of the intestine;
(b)implanting a therapeutic device inside the intestinal lumen in the bent portion of the intestine, wherein the therapeutic device comprises a reservoir and a catheter, wherein the reservoir contains a therapeutic substance, wherein the therapeutic device is configured to administer the therapeutic substance via the catheter, wherein the act of implanting the therapeutic device comprises positioning the catheter in the intestine, wherein the act of implanting the therapeutic device further comprises positioning the reservoir within the intestinal lumen in the bent portion of the intestine; and
(c) securing the therapeutic device inside the intestinal lumen in the bent portion of the intestine.

Assignees

• Ethicon Endo Surgery Inc

Inventors

• Albrecht Thomas E
• Cropper Michael S
• Harris Jason L
• Hess Christopher J
• Hunt John V
• Overmyer Mark D
• Shelton Iv Frederick E
• Stokes Michael J
• Weisenburgh Ii William B
• Widenhouse Tamara S Vetro
• Zwolinski Andrew M

Classifications

• A61F5/0079

  Pyloric or esophageal obstructions · CPC title

• A61F5/0013

  Implantable devices or invasive measures · CPC title

• A61F2/04 Primary

  Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95) · CPC title

• A61F2002/045

  Stomach, intestines · CPC title

• A61F5/0026

  Anti-eating devices using electrical stimulation · CPC title