Method of determining a gradient impulse response function during execution of a magnetic resonance imaging or spectroscopy sequence

Patent metadata

Field	Value
Publication number	US-10379190-B2
Application number	US-201615573284-A
Country	US
Kind code	B2
Filing date	May 12, 2016
Priority date	May 12, 2015
Publication date	Aug 13, 2019
Grant date	Aug 13, 2019

Abstract

A method of determining an actual gradient impulse response function during execution of a magnetic resonance (MR) imaging or spectroscopy sequence, wherein a main magnetic field is generated in a sample region of an MR apparatus by means of a main magnet and wherein superimposed time dependent gradient fields and radiofrequency fields in a first RF band are generated in the sample region according to a first MR sequence for forming images or spectra, the gradient fields being generated by gradient forming means of the MR apparatus operated according to a gradient forming sequence part of said first MR sequence, the MR apparatus further comprising at least one magnetic field probe. The method comprises the steps of: —operating said at least one magnetic field probe according to a second sequence, whereby a time dependent probe signal is repeatedly acquired from each magnetic field probe during a probe acquisition time window, thus providing at least one time dependent probe signal; —obtaining said actual gradient impulse response function by calculating an impulse response function from said at least one time dependent probe signal and from said gradient forming sequence part.

First claim

The invention claimed is:

1. A method of determining an actual gradient impulse response function during execution of a magnetic resonance (MR) imaging or spectroscopy sequence, wherein a main magnetic field is generated in a sample region of an MR apparatus by means of a main magnet and wherein superimposed time dependent gradient fields and radiofrequency fields in a first RF band are generated in the sample region according to a first MR sequence for forming images or spectra, the gradient fields being generated by gradient forming means of the MR apparatus operated according to a gradient forming sequence part of said first MR sequence, the MR apparatus further comprising at least one magnetic field probe, each one of said magnetic field probes being located at a pre-determined position and comprising a magnetic resonance (MR) active substance, means for pulsed MR excitation of said substance and means for receiving a probe MR signal generated by said substance, wherein said pulsed MR excitation and said probe MR signal is in a second RF band that does not overlap said first RF band, the method comprising the steps of:
operating said at least one magnetic field probe according to a second sequence, whereby a time dependent probe signal is repeatedly acquired from each magnetic field probe during a probe acquisition time window, thus providing at least one time dependent probe signal;
obtaining said actual gradient impulse response function by calculating an impulse response function from said at least one time dependent probe signal and from said gradient forming sequence part.

2. The method according to claim 1 , wherein said gradient forming sequence part is substantially periodic with a first repetition time t R1 and a minimum time gap t G between successive probe acquisition time windows is substantially larger than the sampling time required to cover the full bandwidth of the gradient forming sequence, with the provision that if said second sequence is substantially periodic with a second repetition time t R2 then said repetition times t R1 and t R2 shall be incommensurable.

3. The method according to claim 2 , wherein said first RF band is selected for MR of 1 H nuclei and wherein said second RF band is selected for MR of 19 F nuclei.

4. The method according to claim 2 , wherein the MR apparatus comprises a plurality of at least four magnetic field probes.

5. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 2 , wherein said actual gradient impulse response function is used to update a system calibration of said apparatus.

6. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 2 , wherein said actual gradient impulse response function is used for reconstruction of images or spectra obtained with said first MR sequence.

7. The method according to claim 1 , wherein the time gap between successive probe acquisition time windows is equal to or smaller than the sampling time required to cover the bandwidth of the gradient forming sequence.

8. The method according to claim 7 , wherein said first RF band is selected for MR of 1 H nuclei and wherein said second RF band is selected for MR of 19 F nuclei.

9. The method according to claim 7 , wherein the MR apparatus comprises a plurality of at least four magnetic field probes.

10. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 7 , wherein said actual gradient impulse response function is used to update a system calibration of said apparatus.

11. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 7 , wherein said actual gradient impulse response function is used for reconstruction of images or spectra obtained with said first MR sequence.

12. The method according to 1 , wherein said first RF band is selected for MR of 1 H nuclei and wherein said second RF band is selected for MR of 19 F nuclei.

13. The method according to claim 12 , wherein the MR apparatus comprises a plurality of at least four magnetic field probes.

14. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 12 , wherein said actual gradient impulse response function is used to update a system calibration of said apparatus.

15. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 12 , wherein said actual gradient impulse response function is used for reconstruction of images or spectra obtained with said first MR sequence.

16. The method according to claim 1 , wherein the MR apparatus comprises a plurality of at least four magnetic field probes.

17. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 16 , wherein said actual gradient impulse response function is used to update a system calibration of said apparatus.

18. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 16 , wherein said actual gradient impulse response function is used for reconstruction of images or spectra obtained with said first MR sequence.

19. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 1 , wherein said actual gradient impulse response function is used to update a system calibration of said apparatus.

20. A method of operating an MR imaging or spectroscopy apparatus, comprising the step of determining an actual gradient impulse response function according to claim 1 , wherein said actual gradient impulse response function is used for reconstruction of images or spectra obtained with said first MR sequence.

Assignees

• Eidgenossische Technische Hochschule
• Univ Zuerich
• Eidgenossische Technische Hochschule Eth Eth Zentrum

Inventors

• Wilm Bertram
• Barmet Christoph
• Prussmann Klaas P

Classifications

• G01R33/389

  Field stabilisation {, e.g. by field measurements and control means or indirectly by current stabilisation} · CPC title

• G01R33/56518 Primary

  due to eddy currents, e.g. caused by switching of the gradient magnetic field · CPC title

• G01R33/58

  Calibration of imaging systems, e.g. using test probes {, Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material} · CPC title

• G01R33/4625

  Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis · CPC title