Simultaneous magnetic resonance angiography and perfusion with nuclear magnetic resonance fingerprinting

Patent metadata

Field	Value
Publication number	US-10379189-B2
Application number	US-201414444737-A
Country	US
Kind code	B2
Filing date	Jul 28, 2014
Priority date	Jul 28, 2014
Publication date	Aug 13, 2019
Grant date	Aug 13, 2019

Abstract

Embodiments associated with combined magnetic resonance angiography and perfusion (MRAP) and nuclear magnetic resonance (NMR) fingerprinting are described. One example apparatus repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The apparatus includes a signal logic that produces an NMR signal evolution from the NMR signals and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The apparatus includes an MRAP logic that simultaneously performs MR angiography and produces quantitative perfusion maps. A multi-factor MR bio-imaging panel is produced from a combination of the data provided by the MRAP and NMR fingerprinting. Diagnoses may be made from the multi-factor MR bio-imaging panel.

First claim

What is claimed is:

1. An apparatus, comprising:
a nuclear magnetic resonance (NMR) apparatus, comprising a computing device and a display, the computing device including a microprocessor configured to control the NMR apparatus and that is further configured to perform a combined magnetic resonance angiography and perfusion (MRAP)/magnetic resonance fingerprinting (MRF) (MRAP/MRF) excitation to acquire, via the microprocessor configured to perform simultaneous MRAP/MRF acquisition, a first set of data and a second set of data simultaneously,
wherein the first set of data repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals, where members of the first set of data are associated with different points in the (k, t, E) space, where k is data acquired by the NMR apparatus, t is time, and E includes at least one of, T 1 , T 2 , and one other parameter, T 1 being spin-lattice relaxation, and T 2 being spin-spin relaxation, and where one or more of, t and E, vary non-linearly, and
wherein the second set of data includes magnetic resonance (MR) angiographic data and perfusion data;
the microprocessor further configured to communicate with the NMR apparatus and is programmed to:
acquire the first set of data and the second set of data, simultaneously, from the object using the MRAP/MRF acquisition;
produce one or more quantitative relaxation parameter, a magnetic resonance angiogram (MRA), and a quantitative perfusion measurement associated with the object, wherein the one or more quantitative relaxation parameter is produced based on the first set of data, and wherein the MRA and the quantitative perfusion measurement are produced based on the second set of data;
produce information concerning vascularization associated with the object based, at least in part, on the one or more quantitative relaxation parameter, the MRA, and the quantitative perfusion measurement; and
display the information concerning vascularization associated with the object on the display.

2. The apparatus of claim 1 , controlled by the microprocessor, wherein the NMR apparatus is configured to generate the first data set by applying RF energy to the object in a series of variable sequence blocks to elicit one or more resonant species in the object to simultaneously produce the set of NMR signals, and acquire the set of NMR signals from the object in response to the RF energy to produce the (k, t, E) space.

3. The apparatus of claim 2 further comprising an auto-injector, controlled by the microprocessor, where the first set of data and the second set of data are produced after the auto-injector administers a contrast agent to the object.

4. The apparatus of claim 3 , controlled by the microprocessor, where the administration of the contrast agent is a single administration.

5. The apparatus of claim 1 , wherein the quantitative relaxation parameter includes a T 1 relaxation associated with the object, a T 2 relaxation associated with the object, a diffusion coefficient associated with the object, a spin density associated with the object, a proton density associated with the object, a magnetic field to which the object was exposed, or a gradient field to which the object was exposed.

6. The apparatus of claim 1 , wherein the object is a patient and wherein the microprocessor is further configured to diagnose a disease, comprising peripheral arterial disease, in the patient based, at least in part, on the one or more quantitative relaxation parameter, the MRA, and the quantitative perfusion measurement.

7. The apparatus of claim 1 , wherein the object is a patient and wherein the microprocessor is further configured to diagnose a severity of a disease, comprising peripheral arterial disease, in the patient based, at least in part, on the one or more quantitative relaxation parameter, the MRA, and the quantitative perfusion measurement.

8. The apparatus of claim 1 , wherein the microprocessor is further configured to identify the efficacy of a treatment to the object based, at least in part, on the one or more quantitative relaxation parameter, the MRA, and the quantitative perfusion measurement.

9. The apparatus of claim 1 , wherein the microprocessor is further configured to produce an MR image of the object based, at least in part, on the first set of data.

10. The apparatus of claim 1 , wherein the microprocessor is further configured to produce an MR image of the object based, at least in part, on the second set of data.

11. The apparatus of claim 1 , wherein the microprocessor is further configured to produce an MR image of the object based, at least in part, on the first set of data and the second set of data.

12. The apparatus of claim 1 , wherein displaying the information concerning vascularization associated with the object further comprises producing an image concerning vascularization associated with the object based, at least in part, on the one or more quantitative relaxation parameter, the MRA, and the quantitative perfusion measurement.

13. The apparatus of claim 1 , wherein the information concerning vascularization associated with the object is associated with an organ.

14. The apparatus of claim 1 , wherein the information concerning vascularization associated with the object is associated with a tumor.

15. The apparatus of claim 1 , wherein the microprocessor is further configured to acquire the first set of data and the second set of data using a single MRAP/MRF acquisition.

Assignees

• Univ Case Western Reserve

Inventors

• Gulani Vikas
• Griswold Mark
• Ma Dan
• Wright Katherine
• Seiberlich Nicole

Classifications

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• A61B5/4064

  Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369) · CPC title

• G01R33/56366

  Perfusion imaging · CPC title

• A61B5/0035

  adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography · CPC title

• G01R33/448

  Relaxometry, i.e. quantification of relaxation times or spin density (G01R33/50 takes precedence) · CPC title