Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
US-2015368676-A1 · Dec 24, 2015 · US
Methods and materials for the production of monomers for nylon-4/polyester production
US10377899B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10377899-B2 |
| Application number | US-201816100119-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 9, 2018 |
| Priority date | Dec 22, 2014 |
| Publication date | Aug 13, 2019 |
| Grant date | Aug 13, 2019 |
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Abstract
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This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.
First claim
Opening claim text (preview).
What is claimed is: 1. A recombinant host microorganism comprising: exogenous nucleic acids encoding (I) a glutamate decarboxylase (EC 4.1.1.15), and (II) an alcohol dehydrogenase selected from the group consisting of a 4-hydroxybutyrate dehydrogenase and a 5-hydroxyvalerate dehydrogenase, and (III) a first ω-transaminase (EC 2.6.1.29); or exogenous nucleic acids encoding (A) a 2-oxoglutarate decarboxylase (EC 4.1.1.71), and (B) an alcohol dehydrogenase selected from the group consisting of a 4-hydroxybutyrate dehydrogenase and a 5-hydroxyvalerate dehydrogenase, wherein the recombinant host produces 4-hydroxybutyrate. 2. The recombinant host microorganism of claim 1 , said host (i) further comprising an exogenous carboxylate reductase (EC 1.2.99.6), a second and a third exogenous ω-transaminase, and an exogenous alcohol dehydrogenase, wherein the recombinant host further produces putrescine; or (ii) further comprising an exogenous carboxylate reductase and an exogenous alcohol dehydrogenase, wherein the recombinant host further produces 1,4-butanediol.
Assignees
Inventors
Classifications
transferring nitrogenous groups (2.6) · CPC title
Glutamate decarboxylase (4.1.1.15) · CPC title
to carbon atoms of acyclic carbon skeletons · CPC title
Hydroxy-carboxylic acids · CPC title
Amines; Imines · CPC title
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Frequently asked questions
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- What does patent US10377899B2 cover?
- This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.
- Who is the assignee on this patent?
- Invista North America Sarl
- What technology area does this patent fall under?
- Primary CPC classification C12P7/18. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 13 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).