Bi-aromatic propynyl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof

Patent metadata

Field	Value
Publication number	US-10377694-B2
Application number	US-201715424341-A
Country	US
Kind code	B2
Filing date	Feb 23, 2017
Priority date	Feb 3, 2016
Publication date	Aug 13, 2019
Grant date	Aug 13, 2019

Abstract

The invention relates to new compounds of the general formula (I):

as well as the use thereof in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, in particular), or in the use of cosmetic compositions.

First claim

The invention claimed is:

1. A bi-aromatic propynyl compound selected from:

or a salt thereof.

2. The compound according to claim 1 , wherein the compound is

(compound 1), or a salt thereof.

3. The compound according to claim 1 , wherein the compound is

(compound 2), or a salt thereof.

4. A pharmaceutical composition comprising a bi-aromatic propynyl compound selected from

(compound 1) and

(compound 2),
or a salt thereof.

5. The pharmaceutical composition according to claim 4 , wherein the compound is

(compound 1), or a salt thereof.

6. The pharmaceutical composition according to claim 4 , wherein the compound is

(compound 2), or a salt thereof.

7. The pharmaceutical composition according to claim 4 , wherein the composition further comprises a pharmaceutically acceptable carrier.

8. The pharmaceutical composition according to claim 4 , wherein the composition is formulated for enteral, parenteral, topical, or ocular administration.

9. The pharmaceutical composition according to claim 8 , wherein the composition is formulated for ocular administration.

10. The pharmaceutical composition according to claim 8 , wherein the composition is formulated for enteral administration.

11. The pharmaceutical composition according to claim 4 , wherein the composition is in the form of a tablet, hard capsule, dragee, syrup, suspension, solution, powder, granulate, emulsion, microsphere, nanosphere, lipid or polymer vesicle, ointment, cream, milk, pomade, powder, swab, gel, spray, lotion, polymer patch, hydrogel, soap, shampoo, or eye drop.

12. The pharmaceutical composition according to claim 11 , wherein the composition is in the form of an eye drop.

13. The pharmaceutical composition according to claim 11 , wherein the composition is in the form of a tablet.

14. The pharmaceutical composition according to claim 11 , wherein the composition is in the form of a hard capsule.

15. The pharmaceutical composition according to claim 11 , wherein the composition is in the form of an emulsion.

16. The pharmaceutical composition according to claim 11 , wherein the composition is in the form of a microsphere.

17. The pharmaceutical composition according to claim 4 , wherein the compound is formulated for administration in a daily dosage of 0.01 mg/kg to 100 mg/kg bodyweight in 1 to 3 doses.

Assignees

• Galderma Res & Dev

Inventors

• Portal Thibaud

Classifications

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P27/02

  Ophthalmic agents · CPC title