Triarylmethane analogs and their use in treating cancers

Patent metadata

Field	Value
Publication number	US-10376522-B2
Application number	US-201615173946-A
Country	US
Kind code	B2
Filing date	Jun 6, 2016
Priority date	Dec 31, 2007
Publication date	Aug 13, 2019
Grant date	Aug 13, 2019

Abstract

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogs of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.

First claim

The invention claimed is:

1. A pharmaceutical composition comprising liposomes containing a compound defined by the formula below

or a pharmaceutically acceptable salt thereof, wherein
n is 1-4;
R is H or substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl, or arylalkyl;
X is H, amino, hydroxy, ether, thiol, or thiolether; and
Z is an optional substituent selected from halo, hydroxyl, thiol, ester, amide, carboxy, sulfoxy, nitrile, azido, alkyl, alkenyl, alkynyl, nitro, amino, aryl, heteroaryl, phosphonate, and fulvene.

2. The composition of claim 1 , wherein the compound is defined by formula

3. The composition of claim 1 , wherein the compound is defined by formula

4. The composition of claim 1 , wherein the compound is imipramine blue defined by formula

or a pharmaceutically acceptable salt thereof.

Assignees

• Univ Emory
• U S Government As Represented By The Dept Of Veterans Affairs
• U S Government As Represented By The Dept Of Va

Inventors

• Arbiser Jack L

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P35/04

  specific for metastasis · CPC title

• A61P35/02

  specific for leukemia · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P33/06

  Antimalarials · CPC title