Block copolymers and self-assembling nanoparticles formed therefrom

Patent metadata

Field	Value
Publication number	US-10376468-B2
Application number	US-201715832157-A
Country	US
Kind code	B2
Filing date	Dec 5, 2017
Priority date	Dec 5, 2017
Publication date	Aug 13, 2019
Grant date	Aug 13, 2019

Abstract

The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.

First claim

What is claimed is:

1. A block copolymer comprising:
a hydrophilic block; and
a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula I:

wherein m is 114 and x is 5.

2. The block copolymer of claim 1 , capable of self-assembly into a nanoparticle in which the hydrophobic block forms a core of the nanoparticle and the hydrophilic block forms a shell of the nanoparticle.

3. A block copolymer comprising:
a hydrophilic block; and
a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula I:

wherein m is 228 and x is 10.

4. A block copolymer comprising:
a hydrophilic block; and
a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula II:

wherein n is 114 and y is 10.

5. A block copolymer comprising:
a hydrophilic block; and
a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula II:

wherein n is 228 and y is 10.

6. A block copolymer comprising:
a hydrophilic block; and
a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula III:

wherein p is 114 and z is 5.

7. A block copolymer comprising:
a hydrophilic block; and
a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula III:

wherein p is 228 and z is 5.

8. A micellar particle comprising:
a hydrophilic shell; and
a hydrophobic core within the hydrophilic shell,
the hydrophilic shell and the hydrophobic core formed from the nanoparticle of claim 2 .

9. The block copolymer of claim 3 , capable of self-assembly into a nanoparticle in which the hydrophobic block forms a core of the nanoparticle and the hydrophilic block forms a shell of the nanoparticle.

10. A micellar particle comprising:
a hydrophilic shell; and
a hydrophobic core within the hydrophilic shell,
the hydrophilic shell and the hydrophobic core formed from the nanoparticle of claim 9 .

11. The block copolymer of claim 4 , capable of self-assembly into a nanoparticle in which the hydrophobic block forms a core of the nanoparticle and the hydrophilic block forms a shell of the nanoparticle.

12. A micellar particle comprising:
a hydrophilic shell; and
a hydrophobic core within the hydrophilic shell,
the hydrophilic shell and the hydrophobic core formed from the nanoparticle of claim 11 .

13. The block copolymer of claim 5 , capable of self-assembly into a nanoparticle in which the hydrophobic block forms a core of the nanoparticle and the hydrophilic block forms a shell of the nanoparticle.

14. A micellar particle comprising:
a hydrophilic shell; and
a hydrophobic core within the hydrophilic shell,
the hydrophilic shell and the hydrophobic core formed from the nanoparticle of claim 13 .

15. The block copolymer of claim 6 , capable of self-assembly into a nanoparticle in which the hydrophobic block forms a core of the nanoparticle and the hydrophilic block forms a shell of the nanoparticle.

16. A micellar particle comprising:
a hydrophilic shell; and
a hydrophobic core within the hydrophilic shell,
the hydrophilic shell and the hydrophobic core formed from the nanoparticle of claim 15 .

17. The block copolymer of claim 7 , capable of self-assembly into a nanoparticle in which the hydrophobic block forms a core of the nanoparticle and the hydrophilic block forms a shell of the nanoparticle.

18. A micellar particle comprising:
a hydrophilic shell; and
a hydrophobic core within the hydrophilic shell,
the hydrophilic shell and the hydrophobic core formed from the nanoparticle of claim 17 .

Assignees

• IBM
• Inst Of Bioengineering And Nanotechnology Biomedical Sciences Inst

Inventors

• Boday Dylan
• Chin Willy
• Fevre Mareva B
• GARCIA Jeannette
• Hedrick James L
• Leong Eunice
• Park Nathaniel H
• Wojtecki Rudy J
• Yang Yi Yan

Classifications

• A61K31/704

  attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} · CPC title

• C08G64/025

  containing sulfur · CPC title

• C08G64/183

  containing polyether sequences · CPC title

• A61K9/1075 Primary

  Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence) · CPC title

• C08G83/008

  Supramolecular polymers · CPC title