Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Patent metadata

Field	Value
Publication number	US-10376143-B2
Application number	US-201314145404-A
Country	US
Kind code	B2
Filing date	Dec 31, 2013
Priority date	Jul 25, 2003
Publication date	Aug 13, 2019
Grant date	Aug 13, 2019

Abstract

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

First claim

What is claimed is:

1. An electrochemical continuous glucose sensor configured for implantation in a host, the glucose sensor comprising:
an ex vivo portion and an in vivo portion, wherein the in vivo portion comprises:
a working electrode comprising a plurality of electroactive surfaces each configured to measure a signal indicative of a glucose concentration of a host, wherein the plurality of electroactive surfaces comprise a first electroactive surface, a second electroactive surface, and a third electroactive surface, wherein the plurality of electroactive surfaces are spaced along a substantial length of an in vivo portion of the glucose sensor, wherein the in vivo portion of the glucose sensor comprises a distal end;
a membrane covering at least a portion of the working electrode, wherein the membrane comprises an enzyme configured to react with glucose; and
a reference electrode comprising an electroactive surface, wherein the reference electrode electroactive surface comprises a fourth electroactive surface;

wherein the first electroactive surface, the second electroactive surface, the third electroactive surface, and the fourth electroactive surface share a central axis, wherein the central axis is an axis of sensor insertion, wherein first electroactive surface, the second electroactive surface, and the third electroactive surface are closer to the distal end of the in vivo portion of the sensor than the fourth electroactive surface.

2. The glucose sensor of claim 1 , wherein each of the electroactive surfaces is shaped like a circle.

3. The glucose sensor of claim 1 , wherein each of the electroactive surfaces is shaped like a dot.

4. The glucose sensor of claim 1 , wherein the plurality of electroactive surfaces all have a substantially equal area.

5. The glucose sensor of claim 1 , wherein the plurality of electroactive surfaces are each spaced apart from at least one adjacent electroactive surface by a substantially equal distance.

6. The glucose sensor of claim 1 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough, wherein the layer comprises polyurethane.

7. The glucose sensor of claim 1 , wherein the glucose sensor has a planar shape.

8. The glucose sensor of claim 1 , wherein the plurality of electroactive surfaces comprise more than three electroactive surfaces.

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Boock Robert J
• Brister Mark C
• Rixman Monica A
• Woo Kum Ming
• Nguyen Lisa
• Brunner Seth R
• Chee Arthur
• Nicholas Melissa A
• Wightlin Matthew D
• Pryor Jack
• Markovic Dubravka

Classifications

• A61B5/6848

  Needles · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/1486

  using enzyme electrodes, e.g. with immobilised oxidase · CPC title

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title