Method of operating continuous sterilizing apparatus, continuous sterilizing apparatus, fermenting system, and continuous fermenting system

Patent metadata

Field	Value
Publication number	US-10370633-B2
Application number	US-201414899624-A
Country	US
Kind code	B2
Filing date	Jun 23, 2014
Priority date	Jun 24, 2013
Publication date	Aug 6, 2019
Grant date	Aug 6, 2019

Abstract

A continuous sterilizing apparatus circulates, through members constituting a flow channel, a sterilizing medium that sterilizes the members to sterilize the members, circulates a sterilizing liquid subjected to sterilization treatment through pipes, performs a series of pieces of treatment including heating treatment, holding treatment, and cooling treatment on the sterilizing liquid, controls a flow rate, a temperature, and a pressure to be preset conditions, and switches a liquid to be circulated through the flow channel from the sterilizing liquid to a liquid to be sterilized.

First claim

The invention claimed is:

1. A continuous sterilizing apparatus that sterilizes a liquid to be sterilized, the continuous sterilizing apparatus comprising:
a first circulating unit comprising:
a heating unit configured to heat the liquid to be sterilized;
a holding unit configured to hold the liquid to be sterilized heated by the heating unit at a certain temperature for a certain time; and
a cooling unit configured to cool the liquid to be sterilized held by the holding unit and for which heating sterilization has been completed,
wherein the first circulating unit circulates at least the liquid to be sterilized;

a second circulating unit including:
a first pipe, one end of which introduces a sterilizing medium that sterilizes members by which a first flow channel is formed and another end of which is connected to a downstream side of the first circulating unit;
a second pipe, one end of which introduces a sterilizing liquid subjected to one or more sterilization treatments and another end of which is connected to an upstream side of the first circulating unit; and
a third pipe, one end of which is connected to the first pipe and another end of which is connected to the second pipe, the second circulating unit forming a ring-shaped second flow channel along with the first circulating unit;
a measuring unit that measures a flow rate, a temperature, and a pressure of a liquid circulating through the first circulating unit;
a storage unit that stores a flow rate, a temperature, and a pressure related to one or more sterilization treatments on the liquid to be sterilized as condition information; and
a controller that controls entire operation of the continuous sterilizing apparatus, the controller configured to:
control the second circulating unit so as to circulate the sterilizing medium through the first and the second circulating units to sterilize the first and the second circulating units and then circulate the sterilizing liquid through the first circulating unit;
perform a series of pieces of treatment by the heating unit, the holding unit, and the cooling unit on the sterilizing liquid and cause the measuring unit to measure a flow rate, a temperature, and a pressure of the sterilizing liquid subjected to the series of pieces of treatment, and
compare the flow rate, the temperature, and the pressure measured by the measuring unit to the condition information stored in the storage unit, determine whether the measured flow rate, temperature, and pressure satisfy conditions corresponding to the condition information, and control the first and the second circulating units, when it is determined that the conditions are satisfied, to switch a liquid to be circulated through the first circulating unit from the sterilizing liquid to the liquid to be sterilized.

2. The continuous sterilizing apparatus according to claim 1 , wherein
the sterilizing medium is steam, and
the continuous sterilizing apparatus further comprises a fourth circulating unit connected to the first circulating unit, the fourth circulating unit being configured to drain discharge generated by the steam.

3. The continuous sterilizing apparatus according to claim 1 , further comprising a heat exchange unit that causes heat exchange between respective liquids that circulate through an upstream side of the heating unit and a downstream side of the holding unit.

4. The continuous sterilizing apparatus according to claim 3 , wherein at least one of the heating unit, the cooling unit, and the heat exchange unit is a plate-type heat exchanger.

5. A fermenting system comprising:
a raw material holding unit that holds a raw material such as a culture medium, a food product, and a pharmaceutical;
a continuous sterilizing apparatus continuously sterilizing the raw material supplied from the raw material holding unit as the liquid to be sterilized, the continuous sterilizing apparatus comprising:
a first circulating unit comprising:
a heating unit that heats the liquid to be sterilized;
a holding unit that holds the liquid to be sterilized heated by the heating unit at a certain temperature for a certain time; and
a cooling unit that cools the liquid to be sterilized held by the holding unit and for which heating sterilization has been completed,
wherein the first circulating unit circulates at least the liquid to be sterilized;

a second circulating unit including:
a first pipe, one end of which introduces a sterilizing medium that sterilizes members by which a first flow channel is formed and another end of which is connected to a downstream side of the first circulating unit;
a second pipe, one end of which introduces a sterilizing liquid subjected to one or more sterilization treatments and another end of which is connected to an upstream side of the first circulating unit; and
a third pipe, one end of which is connected to the first pipe and another end of which is connected to the second pipe, the second circulating unit forming a ring-shaped second flow channel along with the first circulating unit;
a measuring unit measures a flow rate, a temperature, and a pressure of a liquid circulating through the first circulating unit;
a storage unit stores a flow rate, a temperature, and a pressure related to one or more sterilization treatments on the liquid to be sterilized as condition information; and
a controller controls entire operation of the continuous sterilizing apparatus, the controller being configured to:
control the second circulating unit so as to circulate the sterilizing medium through the first and the second circulating units to sterilize the first and the second circulating units and then circulate the sterilizing liquid through the first circulating unit;
perform a series of pieces of treatment by the heating unit, the holding unit, and the cooling unit on the sterilizing liquid and cause the measuring unit to measure a flow rate, a temperature, and a pressure of the sterilizing liquid subjected to the series of pieces of treatment, and
compare the flow rate, the temperature, and the pressure measured by the measuring unit with the condition information stored in the storage unit, determine whether the measured flow rate, temperature, and pressure satisfy conditions corresponding to the condition information, and control the first and the second circulating units, when it is determined that the conditions are satisfied, to switch a liquid to be circulated through the first circulating unit from the sterilizing liquid to the liquid to be sterilized; and
a fermenter that performs fermentation treatment using the raw material subjected to sterilization treatment by the continuous sterilizing apparatus.

6. The fermenting system according to claim 5 , wherein the flow rate is determined in accordance with a measurement result by the measuring unit, a weight change of the raw material holding unit, and/or a weight change of the fermenter.

7. The fermenting system according to claim 5 , wherein the sterilizing liquid is introduced to the flow channel via a pipe diverted from a pipe that introduces the sterilizing liquid to the fermenter.

8. A continuous fermenting system comprising:
a fermenting system comprising:
a raw material holding unit that holds a raw material such as a culture medium, a food product, and a pharmaceutical;
a continuous sterilizing apparatus continuously sterilizing the raw material supplied from the raw material holding unit as the liquid to be sterilized, the continuous sterilizing apparatus comprising:
a first circulating unit comprising:
a heating unit that heats the liquid to be sterilized;
a holding unit that holds the liquid to be sterilized heated by the heating unit at a certain temperature for a certain time;

Assignees

• Toray Industries

Inventors

• Mimitsuka Takashi
• Hayakawa Hiroshi
• Morita Ken
• Yamamoto Yuki
• Otsuka Kenichi

Classifications

• A23L3/22

  Human Necessities · mapped topic

• C12M45/00

  Means for pre-treatment of biological substances · CPC title

• C12M33/14

  with filters, sieves or membranes · CPC title

• C12M41/12

  of temperature (controlling the temperature of chemical or physical processes B01J19/0013, heating or cooling apparatus for laboratory use B01L7/00) · CPC title

• C12M45/20

  Heating; Cooling (heating or cooling apparatus for laboratory uses B01L7/00) · CPC title