Optimal pacing configuration via ventricular conduction delays

Patent metadata

Field	Value
Publication number	US-10369368-B2
Application number	US-201615172993-A
Country	US
Kind code	B2
Filing date	Jun 3, 2016
Priority date	Dec 7, 2009
Publication date	Aug 6, 2019
Grant date	Aug 6, 2019

Abstract

An exemplary method for optimizing pacing configuration includes providing distances between electrodes of a series of three or more ventricular electrodes associated with a ventricle; selecting a ventricular electrode from the series; delivering energy to the ventricle via the selected ventricular electrode, the energy sufficient to cause an evoked response; acquiring signals of cardiac electrical activity associated with the evoked response via non-selected ventricular electrodes of the series; based on signals of cardiac electrical activity acquired via the non-selected ventricular electrodes and the distances, determining conduction velocities; based on the conduction velocities, deciding if the selected ventricular electrode is an optimal electrode for delivery of a cardiac pacing therapy; and, if the selected ventricular electrode comprises an optimal electrode for delivery of the cardiac pacing therapy, calling for delivery of the cardiac pacing therapy using the selected ventricular electrode. Various other methods, devices, systems, etc., are also disclosed.

First claim

What is claimed is:

1. A method comprising:
selecting a left ventricular electrode from a series of three or more left ventricular electrodes;
delivering energy to the left ventricle via the selected left ventricular electrode, the energy sufficient to cause an evoked response;
acquiring signals of cardiac electrical activity associated with the evoked response via non-selected left ventricular electrodes of the series, via a right ventricular electrode and via an atrial electrode;
measuring a delay between the evoked response and the cardiac electrical activity associated with the evoked response acquired by the non-selected left ventricular electrodes, the right ventricular electrode and the atrial electrode;
based on the acquired signals, estimating a total ventricular activation time as a function of the longest measured delay between the evoked response and the cardiac electrical activity associated with the evoked response acquired by the non-selected left ventricular electrodes, the right ventricular electrode and the atrial electrode;
based on the estimated total ventricular activation time, deciding if the selected left ventricular electrode comprises an optimal electrode for delivery of a cardiac pacing therapy; and
if the selected left ventricular electrode comprises an optimal electrode for delivery of the cardiac pacing therapy, calling for delivery of the cardiac pacing therapy using the selected left ventricular electrode.

2. The method of claim 1 further comprising:
delivering energy to the right ventricle via a right ventricular electrode, the energy sufficient to cause an evoked response;
acquiring signals of cardiac electrical activity associated with the evoked response via the selected left ventricular electrode; and
wherein the estimating the total activation time comprises considering an activation time based on the acquired signals via the selected left ventricular electrode as associated with the evoked response due to delivery of energy to the right ventricle.

3. The method of claim 1 further comprising, based on the acquired signals for the non-selected left ventricular electrodes, estimating a left ventricular activation time.

4. The method of claim 1 further comprising, based on the acquired signals for the non-selected left ventricular electrodes and the atrial electrode, estimating a left ventricular activation time.

5. The method of claim 1 further comprising, based on the acquired signals for the non-selected left ventricular electrode and the atrial electrode, estimating a right ventricular activation time.

6. The method of claim 1 further comprising determining if a delay between the delivery of the energy and occurrence of cardiac electrical activity associated with the evoked response at the right ventricular electrode exceeds a delay between the delivery of the energy and occurrence of cardiac electrical activity associated with the evoked response at the atrial electrode and, if so, deciding that the selected left ventricular electrode does not comprise an optimal electrode for delivery of the cardiac pacing therapy.

7. A method comprising:
acquiring signals of cardiac electrical activity associated with an intrinsic activation of the heart via individual left ventricular electrodes of a series of three or more electrodes, via a right ventricular electrode and via an atrial electrode;
measuring a delay between the intrinsic activation and the cardiac electrical activity associated with the intrinsic activation acquired by the individual left ventricular electrodes, the right ventricular electrode and the atrial electrode; and
based on the acquired signals, estimating a total ventricular activation time as a function of the longest measured delay between the evoked response and the cardiac electrical activity associated with the intrinsic activation of the heart acquired by the left ventricular electrodes, the right ventricular electrode and the atrial electrode.

Assignees

• Ryu Kyungmoo
• Min Xiaoyi
• Pacesetter Inc

Inventors

• Ryu Kyungmoo
• Min Xiaoyi

Classifications

• A61N1/3684 Primary

  for stimulating the heart at multiple sites of the ventricle or the atrium · CPC title

• A61N1/36843

  Bi-ventricular stimulation · CPC title

• A61N1/36842

  Multi-site stimulation in the same chamber · CPC title

• A61N1/37247

  User interfaces, e.g. input or presentation means · CPC title

• A61N1/371

  Capture, i.e. successful stimulation · CPC title