Cataplasm and method for producing the same

Patent metadata

Field	Value
Publication number	US-10369115-B2
Application number	US-201414913455-A
Country	US
Kind code	B2
Filing date	Aug 21, 2014
Priority date	Aug 23, 2013
Publication date	Aug 6, 2019
Grant date	Aug 6, 2019

Abstract

A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.

First claim

The invention claimed is:

1. A gel patch, comprising:
a plaster layer on a support, the plaster layer comprising:
a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion comprises poly(methyl acrylate/2-ethylhexyl acrylate) and water as a medium, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% at or above the boiling point of the medium and is present in an amount ranging between 2.5 times and 10 times inclusive a mass of the neutralized polyacrylic acid; and
a polyacrylic acid in the amount of 1-5 mass % based on the total mass of the plaster layer, wherein the neutralized polyacrylic acid present in the plaster layer is 1 to 6 mass %, based on a total mass of the plaster layer;
wherein the gel patch has an adhesive force based on an adhesive force of the poly(methyl acrylate/2-ethylhexyl acrylate) in the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion and an adhesive force of the neutralized polyacrylic acid, and
wherein upon application, the adhesive force of the neutralized polyacrylic acid is greater than the adhesive force of the poly(methyl acrylate/2-ethylhexyl acrylate), and the adhesive force of the poly(methyl acrylate/2-ethylhexyl acrylate) increases to become greater than the adhesive force of the neutralized polyacrylic acid as the amount of water in the plaster layer is reduced.

2. The gel patch according to claim 1 , wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion comprises poly(oxyethylene)nonylphenyl ether.

3. The gel patch according to claim 1 , wherein the neutralized polyacrylic acid is partially neutralized polyacrylic acid.

4. The gel patch according to claim 1 , wherein the water present in the plaster layer is greater by mass than the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion present in the plaster layer.

5. The gel patch according to claim 1 , wherein the water present in the plaster layer is at least 4 times greater by mass than the neutralized polyacrylic acid present in the plaster layer.

6. The gel patch according to claim 1 , wherein the neutralized polyacrylic acid, the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion and the water are mixed in a mass ratio of neutralized polyacrylic acid:poly(methyl acrylate/2-ethylhexyl acrylate) emulsion:water=1:2.5-7:5-16.

7. The gel patch according to claim 6 , wherein the mass ratio of neutralized polyacrylic acid:poly(methyl acrylate/2-ethylhexyl acrylate) emulsion:water=1:2.5-7:7-16.

8. The gel patch according to claim 1 , wherein the water present in the plaster layer is 20 to 60 mass % of a total mass of the plaster layer.

9. The gel patch according to claim 1 , wherein a plaster layer mass is 214 to 1000 g/m 2 .

10. The gel patch according to claim 1 , wherein the amount of water in the plaster layer is reduced by evaporation.

11. A method of producing a gel patch according to claim 1 , having an adhesive force and comprising a plaster layer on a support, the method comprising: mixing water, a neutralized polyacrylic acid, a polyacrylic acid, and a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is in an amount ranging between 2.5 times and 10 times inclusive a mass of the neutralized polyacrylic acid to obtain the plaster layer, wherein the adhesive force of the gel patch can be maintained even with a reduction of water content.

12. The gel patch according to claim 2 , wherein the neutralized polyacrylic acid is partially neutralized polyacrylic acid.

13. The gel patch according to claim 2 , wherein the water present in the plaster layer is greater by mass than the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion present in the plaster layer.

14. The gel patch according to claim 3 , wherein the water present in the plaster layer is greater by mass than the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion present in the plaster layer.

15. The gel patch according to claim 2 , wherein the water present in the plaster layer is at least 4 times greater by mass than the neutralized polyacrylic acid present in the plaster layer.

16. The gel patch according to claim 3 , wherein the water present in the plaster layer is at least 4 times greater by mass than the neutralized polyacrylic acid present in the plaster layer.

17. The gel patch according to claim 4 , wherein the water present in the plaster layer is at least 4 times greater by mass than the neutralized polyacrylic acid present in the plaster layer.

18. The gel patch according to claim 2 , wherein the neutralized polyacrylic acid, the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion and the water are mixed in a mass ratio of neutralized polyacrylic acid:poly(methyl acrylate/2-ethylhexyl acrylate) emulsion:water=1:2.5-7:5-16.

Assignees

• Hisamitsu Pharmaceutical Co
• Hisamitsu Pharmaceutical Co Ltd

Inventors

• TSURUSHIMA Keiichiro
• Kose Yasuhisa
• Yamasoto Shinji
• Tsuru Seiichiro
• Yoshinaga Takaaki

Classifications

• A61K9/7061 Primary

  Polyacrylates · CPC title

• C08L33/02

  Homopolymers or copolymers of acids; Metal or ammonium salts thereof · CPC title

• A61L15/585

  Mixtures of macromolecular compounds · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• A61L15/225

  Mixtures of macromolecular compounds · CPC title