Shape-memory-actuated materials for accelerated healing of orthopedic injuries

Patent metadata

Field	Value
Publication number	US-10368993-B2
Application number	US-201715648721-A
Country	US
Kind code	B2
Filing date	Jul 13, 2017
Priority date	Jun 20, 2013
Publication date	Aug 6, 2019
Grant date	Aug 6, 2019

Abstract

A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substrate for engineering periosteal grafts.

First claim

What is claimed is:

1. A method of repairing a bone defect, comprising the steps of:
positioning a porous foam scaffold comprised of a shape memory polymer configured for expansion in response to a stimulus within said bone defect, wherein said porous foam scaffold has a pore size of 200 to 500 micrometers and a porosity of 79 percent plus or minus five percent;
applying a stimulus to said scaffold to cause said porous foam scaffold to expand into said bone defect.

2. The method of claim 1 , wherein said porous foam scaffold comprises a polymer selected from the group consisting of poly(tert-butyl acrylate/butyl acrylate), poly-DL-lactide, and poly-DL-lactide/polyhedral oligomeric silsesquioxane.

3. The method of claim 1 , further comprising the steps of:
positioning a sleeve comprised of a second shape memory polymer that is configured for radial contraction in response to a second stimulus around said bone defect and said porous foam scaffold;
applying said second stimulus to contract said sleeve around said bone defect and said porous foam scaffold.

4. The method of claim 3 , wherein said sleeve comprises a thermoplastic polyurethane.

5. The method of claim 4 , said sleeve includes semi-crystalline polyester fibers.

6. The method of claim 5 , wherein the semi-crystalline polyester fibers comprise poly(L-lactic acid).

Assignees

• Henderson James
• Mather Patrick T
• Univ Syracuse

Inventors

• Henderson James
• Mather Patrick T

Classifications

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61F2210/0014

  using shape memory or superelastic materials, e.g. nitinol · CPC title

• A61F2/2846 Primary

  Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006) · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L27/16

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title