System and method of remotely monitoring and/or managing the treatment of a plurality of subjects with aerosolized medicament

Patent metadata

Field	Value
Publication number	US-10363384-B2
Application number	US-201214003245-A
Country	US
Kind code	B2
Filing date	Mar 16, 2012
Priority date	Mar 16, 2011
Publication date	Jul 30, 2019
Grant date	Jul 30, 2019

Abstract

Therapy regimes of a plurality of subjects are remotely monitored and/or managed, wherein the therapy regimes include reception of aerosolized medicament. This enables users such as medical care providers, researchers, clinic administrators, and/or other users to monitor and/or manage the therapy regimes of the plurality of subjects through a centralized access point. This reduces physical requirements of proximity for the users and/or the subjects, alleviates the administrative burden placed on the users to manage and/or monitor individual therapy regimes, and/or provides other enhancements over convention systems.

First claim

The invention claimed is:

1. A system configured to remotely monitor the therapy of at least one subject, wherein the therapy includes the delivery of a plurality of aerosolized medicaments with at least one drug delivery device and wherein at least one of the plurality of aerosolized medicaments is delivered following an on/off cycle of a predetermined duration of said at least one drug delivery device, said on/off cycle including a delivery period during which said at least one aerosolized medicament is delivered to said subject and a non-delivery period during which said at least one aerosolized medicament is not delivered to said subject, the system comprising:
the at least one drug delivery device; and
a server in communication with the at least one drug delivery device comprising one or more processors configured to execute computer program modules, the computer program modules comprising:
(a) an information acquisition module configured to obtain, over a communications network, therapy information for said subject, wherein therapy information for said subject includes information related to a respiratory capacity of said subject and information conveying one or more breathing parameters of the respiration of said subject during the delivery of the plurality of aerosolized medicaments;
(b) a user interface module configured to generate a definition of a user interface that enables a user to selectively view said therapy information and to enter prescription data relating to said plurality of medicaments, wherein the user interface module is configured to define a treatment view of the user interface, the treatment view comprising information about a frequency and duration of treatments received by said subject during a previous period of time;
(c) a treatment calculation module configured to calculate
(i) a total number of daily treatments to be delivered to said subject, with said at least one drug delivery device, based on said prescription data for individual ones of said plurality of aerosolized medicaments, wherein said calculation module is configured to automatically determine a change of the total number of daily treatments for the individual ones of said plurality of aerosolized medicaments when the therapy enters the delivery period and/or the non-delivery period of the on/off cycle of said at least one drug delivery device,
(ii) a daily actuation time required to aerosolize the individual ones of said plurality of aerosolized medicaments in the at least one drug delivery device, and
(iii) a treatment time target based on the daily actuation time and a nebulization factor corresponding to the individual ones of said plurality of aerosolized medicaments and the at least one drug delivery device, and cause the treatment view to display the treatment time target; and

(d) an alert module configured to cause the treatment view to display information that indicates the change of the total number of daily treatments for the individual ones of said plurality of aerosolized medicaments for a future period of time when the therapy enters the delivery period and/or the non-delivery period of the on/off cycle with the information about the frequency and duration of treatments received by said subject during the previous period of time, wherein the display of information comprises one or more fields in the treatment view, the one or more fields
displaying the total number of daily treatments for the individual ones of said plurality of aerosolized medicaments for the future period of time and the previous period of time, and
displaying the change of the total number of daily treatments for the individual ones of said plurality of aerosolized medicaments for the future period of time, simultaneously with the total number of daily treatments for the individual ones of said plurality of aerosolized medicaments for the future period of time and the previous period of time.

2. The system of claim 1 , wherein the alert module is configured to inform the user and/or said subject that the therapy is about to enter the delivery period and/or the non-delivery period of the on/off cycle.

3. The system of claim 2 , wherein the alert module is configured to provide information related to a change of number of total daily nebulizations for the delivery of the plurality of aerosolized medicaments and/or a date at which the delivery period begins or ends.

4. The system of claim 1 , wherein the prescription data includes the number of daily treatments prescribed by the clinician, the chamber volume of a drug delivery device used in the delivery of the plurality of aerosolized medicaments, the number of chamber fills per treatment for each aerosolized medicament, whether the aerosolized medicament should follow an on/off cycle, and/or the predetermined duration of the on/off cycle.

5. The system of claim 1 , wherein the user interface module is further configured to define:
a device view of the user interface, the device view comprising information related to metrics that quantify drug delivery device performance of said at least one drug delivery device, the metrics comprising:
one or more of a mesh performance, a tidal breathing mode inhalation time, or a rest time; and
a corresponding one or more of a targeted mesh performance, a targeted tidal breathing mode inhalation time, or a targeted rest time;

a prescription view of the user interface, the prescription view comprising information related to a therapy regime prescribed for a group of subjects including said subject;
a record view of the user interface, the record view comprising information related to historical device usage and respiratory function of the group of subjects including said subject; and
a subject grouping view of the user interface, the subject grouping view configured to facilitate viewing, creation of, and/or manipulation of groupings of subjects including said subject.

6. The system of claim 1 , wherein the alert module is configured to cause the treatment view to display the information that indicates the change of the total number of daily treatments for the individual ones of said plurality of aerosolized medicaments for a future period of time when the therapy enters the delivery period and/or the non-delivery period of the on/off cycle with the information about the frequency and duration of treatments received by said subject during the previous period of time via a graph visually displayed in the treatment view.

7. The system of claim 1 , wherein the total number of daily treatments for the individual ones of said plurality of aerosolized medicaments for the future period of time and the previous period of time is displayed in a first field, and the change of the total number of daily treatments for the future period of time is displayed in a second field, separated by a boundary from the first field.

8. The system of claim 7 , wherein the second field further includes additional information comprising information related to taking a sputum sample, lung function measurements, and/or completing a questionnaire.

9. The system of claim 1 , wherein the treatment time target is calculated based on an average of the daily actuation time of the individual ones of said plurality of aerosolized medicaments and the nebulization factor.

10. A computer implemented method of remotely monitoring the therapy of at least one subject, wherein the therapy includes the delivery of a plurality of aerosolized medicaments with at least one drug delivery device and wherein at least one of the plurality of aerosolized medicaments is delivered following an on/off cycle of a predetermined duration of said at least one drug delivery device, said on/off cycle including

Assignees

• Dyche Anthony
• Rabbetts Ian Philip
• Denyer Jonathan Stanley Harold
• Koninklijke Philips Nv

Inventors

• Dyche Anthony
• Rabbetts Ian Philip
• Denyer Jonathan Stanley Harold

Classifications

• G16H20/13

  delivered from dispensers · CPC title

• A61M16/021

  operated by electrical means (A61M16/202 – A61M16/205 take precedence) · CPC title

• A61M16/14

  by mixing different fluids, one of them being in a liquid phase · CPC title

• A61M16/0051 Primary

  with alarm devices · CPC title

• G16H40/67

  for remote operation · CPC title