Substituted imidazole derivatives and methods of use thereof

Patent metadata

Field	Value
Publication number	US-10363241-B2
Application number	US-201816185234-A
Country	US
Kind code	B2
Filing date	Nov 9, 2018
Priority date	Sep 30, 2009
Publication date	Jul 30, 2019
Grant date	Jul 30, 2019

Abstract

The present invention provides intermediates for methods for synthesizing compounds of Formula (I) and pharmaceutically acceptable salts thereof.

First claim

We claim:

1. A compound of Formula (X)

wherein
Q 1 is selected from the group consisting of —CH 2 OCH 2 CH 3 and —CH 2 CH 2 CH 2 CH 3 .

2. 4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenol.

3. A pharmaceutical composition comprising 4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenol and a pharmaceutically acceptable carrier.

Assignees

• Vtv Therapeutics Llc

Inventors

• Jones David
• Gowda Raju Bore
• Xie Rongyuan

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• C07D233/70

  One oxygen atom · CPC title

• C07D233/64

  with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine · CPC title

• C07D233/60

  with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title