Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use

Patent metadata

Field	Value
Publication number	US-10363236-B2
Application number	US-201815973915-A
Country	US
Kind code	B2
Filing date	May 8, 2018
Priority date	Jan 3, 2011
Publication date	Jul 30, 2019
Grant date	Jul 30, 2019

Abstract

An isothiocyanate functional surfactant, wherein the protonated form of said surfactant is represented by the following chemical structure:

wherein X includes an integer ranging from approximately 1 to approximately 25, and wherein Y includes an integer ranging from approximately 6 to approximately 25.

First claim

What is claimed and desired to be secured by Letters Patent of the United States is:

1. A surfactant formulation, comprising:
a lysine derivative, wherein the lysine derivative comprises an α-nitrogen and a ε-nitrogen, and wherein an alkyl and/or alkanoyl substituent comprising at least 8 carbon atoms is bound to the α-nitrogen, and further wherein the ε-nitrogen forms part of an isothiocyanate functional group.

2. A surfactant formulation, comprising:
a surfactant or a pharmaceutically acceptable salt thereof, wherein the salt of the surfactant is represented by the following chemical structure:

 wherein R 1 is selected from the group consisting of an alkyl and alkanoyl group containing 1 to 25 carbon atom(s); wherein R 2 is selected from the group consisting of NCS; wherein R 3 -R 5 are each independently selected from the group consisting of H; OH; and an alkyl, and alkanoyl group containing 1 to 25 carbon atom(s) with the proviso that at least one of R 3 -R 5 is selected from the group consisting of an alkyl, and alkanoyl, group containing 8 to 25 carbon atoms; and wherein X + comprises a counter cation.

Assignees

• Silver Michael E
• The William M Yarbrough Found

Inventors

• Silver Michael E

Classifications

• A61P17/00

  Drugs for dermatological disorders · CPC title

• C07C331/20

  of a saturated carbon skeleton · CPC title

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K31/198

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title