System and method for portable magnetic resonance imaging using a rotating array of permanent magnets

Patent metadata

Field	Value
Publication number	US-10359481-B2
Application number	US-201214408187-A
Country	US
Kind code	B2
Filing date	Oct 22, 2012
Priority date	Jun 15, 2012
Publication date	Jul 23, 2019
Grant date	Jul 23, 2019

Abstract

A portable magnetic resonance imaging (“MRI”) system that uses static magnetic field inhomogeneities in the main magnet for encoding the spatial location of nuclear spins is provided. Also provided is a spatial-encoding scheme for a low-field, low-power consumption, light-weight, and easily transportable MRI system. In general, the portable MRI system spatially encodes images using spatial inhomogeneities in the polarizing magnetic field rather than using gradient fields. Thus, an inhomogeneous static field is used to polarize, readout, and encode an image of the object. To provide spatial encoding, the magnet is rotated around the object to generate a number of differently encoded measurements. An image is then reconstructed by solving for the object most consistent with the data.

First claim

The invention claimed is:

1. A method for acquiring magnetic resonance imaging data comprising:
a) arranging an object within an inhomogeneous magnetic field relative to a rotation angle;
b) generating a radio frequency (RF) field to the object to excite spins within the object;
c) receiving magnetic resonance signals responsive to the generated RF field from the object;
d) rotating the inhomogeneous magnetic field around the object to a different rotation angle to generate modulations in a phase of the magnetic resonance signals received from the object;
e) repeating steps b) through d) a plurality of times to receive magnetic resonance signals from the object with a plurality of different rotation angles; and
f) reconstructing an image of the object from the received magnetic resonance signals using the modulations in the phase of the magnetic resonance signals to determine spatial encoding of the magnetic resonance signals.

2. The method as recited in claim 1 in which step d) includes rotating an annular array of permanent magnets through one of discrete steps or continuous motion of different rotation angles to rotate the inhomogeneous magnetic field.

3. The method as recited in claim 1 in which step c) includes allowing n radians of relative phase to evolve between neighboring voxels acquire the imaging data while to controlling intravoxel dephasing when receiving the magnetic resonance signals.

4. The portable MRI system as recited in claim 3 in which the longitudinal encoding is achieved using one of a z-dependent spatial phase applied using the RF coil or RF pulses generated with the RF coil having a quadratic phase.

5. The method as recited in claim 1 further comprising generating a magnetic field offset applied relative to the inhomogeneous magnetic field.

6. The method as recited in claim 1 further comprising generating an RF field with a phase that varies linearly along a longitudinal axis of the object.

7. The method as recited in claim 1 further comprising encoding along a longitudinal axis of the object independently of rotating the inhomogeneous magnetic field.

8. The method as recited in claim 1 in which step c) includes controlling a bandwidth of RF field produced in step b) to create a series of constrained spatial regions and using the series of constrained spatial regions when reconstructing the image of the object in step f).

9. The method as recited in claim 8 in which step b) includes controlling against phase and flip angle variation due to off-resonant spin precession.

10. The method as recited in claim 8 in which step f) includes reconstructing the image of the object using an iterative reconstruction process.

11. A portable magnetic resonance imaging (“MRI”) system, comprising:
a magnet assembly comprising:
a longitudinal axis along which a static magnetic field having inhomogeneities is formed;
a controller configured to:
receive magnetic imaging data acquired from an object arranged along the longitudinal axis as a position of the inhomogeneities of the static magnetic field is moved around the longitudinal axis; and
reconstruct the imaging data by spatially decoding the imaging data using the position of the inhomogeneities of the static magnetic field as it is moved around the longitudinal axis.

12. The portable MRI system as recited in claim 11 in which the magnet assembly includes a plurality of magnets and a support configured to hold the magnets in an annular Halbach array arrangement about the longitudinal axis.

13. The portable MRI system as recited in claim 11 in which the magnet assembly further comprises a plurality of end-ring magnets and a support configured to hold the plurality of end-ring magnets in an annular arrangement that is coaxial with the longitudinal axis.

14. The portable MRI system as recited in claim 13 in which the magnet assembly further comprises:
another plurality of magnets, each extending from a proximal end to a distal end along the longitudinal axis of the magnet assembly;
another support that is configured to hold the another plurality of magnets in an annular arrangement that is coaxial with the longitudinal axis such that the another plurality of magnets generate a linear magnetic field that augments the magnetic field generated by the plurality of magnets.

15. The portable MRI system as recited in claim 14 in which the another support is configured to rotate independently of the support and further comprising a rotator coupled to the another support and configured to rotate the another plurality of magnets about the longitudinal axis through a plurality of different rotation angles.

16. The portable MRI system as recited in claim 15 in which the controller is configured to control the rotator and an RF coil to allow radians of relative phase to evolve between neighboring voxels near at least a periphery of the magnet assembly to acquire the imaging data from the object arranged along the longitudinal axis.

17. The portable MRI system as recited in claim 15 in which the controller is configured to control the rotator and the RF coil to control intravoxel dephasing when acquiring the imaging data.

18. The portable MRI system as recited in claim 11 in which the magnet assembly is configured to produce both linear and higher-order components to create the static magnetic field having inhomogeneities.

19. The portable MRI system as recited in claim 11 further comprising at least one of a magnetic field linear gradient or an offset applied to the static magnetic field having inhomogeneities to provide spatial encoding proximate to the longitudinal axis of the magnet assembly.

20. The portable MRI system as recited in claim 11 further comprising a radio frequency (RF) coil configured to generate an RF field whose phase varies along the longitudinal axis of the magnet assembly.

21. The portable MRI system as recited in claim 11 further comprising a radio frequency (RF) coil configured to encode along the longitudinal axis of the magnet assembly independently of encoding by the magnet assembly.

22. The portable MRI system as recited in claim 11 in which the magnet assembly is further configured to generate the static magnetic field to vary along the longitudinal axis of the magnet assembly.

23. The portable MRI system as recited in claim 11 in which the controller is configured to control an array of RF coils and using information about spatially varying coil sensitivities to reconstruct an image of the object.

24. The portable MRI system as recited in claim 11 further comprising:
a rotator coupled to the magnet assembly and configured to rotate the magnet assembly about the longitudinal axis through a plurality of different rotation angles;
a radio frequency (RF) coil for generating RF energy and receiving magnetic resonance signals from an object positioned in the magnet assembly.

25. The portable MRI system as recited in claim 24 in which the controller is configured to control a bandwidth of RF excitation pulses produced by the RF coil to create a series of constrained spatial regions and use the series of constrained spatial regions when reconstructing the image of the object.

26. The portable MRI system as recited in claim 24 in which the controller is configured to acquire the imaging data with longitudinal encoding.

27. The portable MRI system as recited in claim 26 in whic

Assignees

• Wald Lawrence L
• Zimmerman Clarissa
• Stockmann Jason
• Massachusetts Gen Hospital

Inventors

• Wald Lawrence L
• Zimmerman Clarissa
• Stockmann Jason

Classifications

• G01R33/4824

  using a non-Cartesian trajectory · CPC title

• G01R33/445

  MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging · CPC title

• A61B5/0042 Primary

  for the brain · CPC title

• G01R33/383

  using permanent magnets · CPC title

• A61B5/055 Primary

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title