Magnesium-zinc-calcium alloy, method for production thereof, and use thereof

Patent metadata

Field	Value
Publication number	US-10358709-B2
Application number	US-201314395713-A
Country	US
Kind code	B2
Filing date	Jun 24, 2013
Priority date	Jun 26, 2012
Publication date	Jul 23, 2019
Grant date	Jul 23, 2019

Abstract

A magnesium alloy includes 3 to 7.0% Zn, 0.001 to 0.5% Ca, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of intermetallic phases, in a total amount of no more than 0.005 of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P, wherein the alloying elements are selected from the group of the rare earths having the ordinal numbers 21, 39, 57 to 71 and 89 to 103 in a total amount of no more than 0.001% by weight.

First claim

The invention claimed is:

1. A biodegradable implant formed from a magnesium alloy having improved mechanical and electrochemical properties, the magnesium alloy comprising: 3 to 7% by weight Zn, 0.001 to 0.5% by weight Ca, the remainder being high-purity vacuum distilled magnesium, the magnesium alloy containing total impurities, which promote electrochemical potential differences and/or the formation of intermetallic phases, in a total amount of no more than 0.0048% by weight wherein the total impurity contains:
individual impurities selected from the group of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P in an amount of not more than 0.0038% of weight; and
alloying elements selected from the group of the rare earths having the ordinal numbers 21, 39, 57 to 71 and 89 to 103 in an amount of no more than 0.001% by weight;
wherein the biodegradable implant has a tensile strength of >275 MPa, a yield point of >200 MPa, and a yield ratio of <0.8, and wherein the difference between the tensile strength and yield point is >50 MPa;
wherein the magnesium alloy contains an intermetallic Ca 2 Mg 6 Zn 3 phase; and
wherein the implant has improved corrosion resistance.

2. The implant according to claim 1 , wherein the total impurities have an amount in total of no more than 0.0045% by weight.

3. The implant according to claim 1 , wherein the content of Zn is 3 to 5% by weight and that of Ca is at least 0.2 to 0.4% by weight, wherein the alloy contains an intermetallic Ca 2 Mg 6 Zn 3 phase in a volume content of greater than 0 to 2%.

4. The implant according to claim 1 , total impurities amount to the following in % by weight: Fe<0.0005; Si<0.0005; Mn<0.0005; Co<0.0005; Ni<0.0005; Cu<0.0005; Al<0.0003; Zr<0.0003; P<0.0002.

5. The implant according to claim 1 , wherein the impurity elements Fe, Si, Mn, Co, Ni, Cu and Al total no more than 0.0033% by weight, the content of Al is no more than 0.0003% by weight, and the content of Zr is no more than 0.0001% by weight.

6. The implant according to claim 1 , wherein individual elements from the group of the rare earths together total no more than 0.001% by weight.

7. The implant according to claim 1 , wherein the alloy has a fine-grained microstructure having a grain size of less than 7.5 μm, without considerable electrochemical potential differences between the individual matrix phases.

8. The implant according claim 1 , wherein the alloy contains an intermetallic Ca 2 Mg 6 Zn 3 phase and a precipitable MgZn phase, and the intermetallic Ca 2 Mg 6 Zn 3 phase is at least equally as noble as, or less noble, and the precipitable MgZn phase is more noble, than the matrix phases.

9. The implant according to claim 1 , wherein precipitations have a size of <5 μm and are dispersely distributed at the grain boundaries or in the grain interior.

10. The implant according to claim 1 , wherein the mechanical asymmetry is <1.25.

11. The implant of claim 1 , comprising one of stents, implants for fastening and temporarily fixing tissue implants and tissue transplantations, orthopedic and dental implants, and neuroimplants.

12. The implant according to claim 1 , wherein the total impurities have an amount in total of no more than 0.0036% by weight.

13. The implant according to claim 1 , wherein the impurity elements Fe, Si, Mn, Co, Ni, Cu and Al total no more than 0.0022% by weight, and the content of Al is no more than 0.0001% by weight.

14. The implant according to claim 13 , wherein the impurity elements Fe, Si, Mn, Co, Ni, Cu and Al total no more than 0.00095% by weight, and the content of Al is no more than 0.00005% by weight.

15. The implant according to claim 1 , wherein individual elements from the group of the rare earths together total no more than 0.0005% by weight.

16. The implant according to claim 1 , wherein individual elements from the group of the rare earths together total no more than 0.0003% by weight.

17. The implant according to claim 1 , wherein precipitations have a size of <1 μm and are dispersely distributed at the grain boundaries or in the grain interior.

18. The implant according to claim 1 , having a tensile strength of >300 MPa, a yield point of >225 MPa, and a yield ratio of <0.75, wherein the difference between the tensile strength and yield point is >100 MPa, and the mechanical asymmetry is <1.25.

19. The implant according to claim 1 , wherein the magnesium alloy forms a body of a cardiovascular implant.

20. The implant according to claim 1 , wherein magnesium alloy comprises 5 to 7% by weight Zn, or 0.4 to 0.5% by weight Ca, or both.

Assignees

• Biotronik Ag

Inventors

• Mueller Heinz
• Uggowitzer Peter
• Loeffler Joerg

Classifications

• A61L2430/12

  for dental implants or prostheses · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• C22C1/02

  by melting {(C22C1/1036 takes precedence)} · CPC title

• C22F1/06 Primary

  of magnesium or alloys based thereon · CPC title

• C22C23/04 Primary

  with zinc or cadmium as the next major constituent · CPC title