Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief

Patent metadata

Field	Value
Publication number	US-10357464-B2
Application number	US-201113183257-A
Country	US
Kind code	B2
Filing date	Jul 14, 2011
Priority date	Sep 20, 2006
Publication date	Jul 23, 2019
Grant date	Jul 23, 2019

Abstract

The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.

First claim

What is claimed is:

1. A method for reducing pain perception in a mammalian subject in need of such pain reduction, the method consisting of topically administering to the skin of said subject a topical patch consisting of sevoflurane and one or more pharmaceutically acceptable carriers in an amount effective to reduce pain perception in the subject,
wherein the administering does not result in general anesthesia in the subject, and wherein the subject is not under general anesthesia;
wherein the topical administration results in analgesia;
wherein the volatile anesthetic is the only analgesic agent present in the pharmaceutical preparation in an amount sufficient to reduce pain in said subject; wherein the topical administration is not by inhalation;
and wherein said topical administration reduces pain perception in the subject.

2. The method of claim 1 , wherein the method comprises treating chronic pain in the subject.

3. The method of claim 1 , wherein the method comprises treating acute pain in the subject.

4. The method of claim 1 , wherein the pharmaceutical preparation is delivered to anesthetize a portion of said subject prior to a surgery.

5. The method of claim 1 , wherein the administration is periodic.

6. The method of claim 1 , wherein the administration is a one-time event.

7. The method of claim 1 , wherein the volatile anesthetic is periodically administered to the subject on separate occasions.

8. The method of claim 1 , wherein the method results in elimination of pain perception of a portion of the body of the subject.

9. The method of claim 1 , wherein the subject is a human.

10. The method of claim 1 , wherein the subject is a mouse or a rat.

Assignees

• Phan Phillip C
• Burton Allen W
• Univ Texas

Inventors

• Phan Phillip C
• Burton Allen W

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• A61P23/00

  Anaesthetics · CPC title

• A61P23/02

  Local anaesthetics · CPC title