Apparatus, method, and program for component measurement

Patent metadata

Field	Value
Publication number	US-10352950-B2
Application number	US-201615261674-A
Country	US
Kind code	B2
Filing date	Sep 9, 2016
Priority date	Mar 14, 2014
Publication date	Jul 16, 2019
Grant date	Jul 16, 2019

Abstract

Provided is a component measuring apparatus configured to determine a functional form that describes wavelength characteristics of a variation attributable to scattering (S (λ)). The apparatus then determines unknown one or more coefficients (p, q) based on a first relational expression that involves a variation attributable to absorption (H (λ 1 )) and a group of second relational expressions that do not involve variations attributable to absorption (H (λ 2 a ), H (λ 2 b ), H (λ 2 c )). The apparatus then corrects an absorbance measured at an arbitrary wavelength (λ) using a function where the one or more coefficients (p, q) are applied to the functional form so as to reduce or eliminate at least the effects of scattering of light.

First claim

The invention claimed is:

1. A component measuring apparatus for measuring an analyte in a bodily fluid based on optical characteristics of a dye component contained in the bodily fluid before or after color reaction, comprising:
an optical measurement system comprising a light emitter and a light receiver;
a processor; and
a memory coupled with and readable by the processor and storing therein instructions that, when executed by the processor, cause the processor to:
instruct the optical measurement system to direct light, via the light emitter, toward a test tip comprising the bodily fluid;
receive a signal corresponding to an amount of the light reflected from the test tip, wherein the signal is provided by the light receiver;
acquire, based on the received signal, a first observed value representing an absorbance at a specific wavelength in a first wavelength region in which a component of the bodily fluid other than the dye component has a first amount of light absorptivity and a group of second observed values representing absorbances at one or more different wavelengths in a second wavelength region in which the component of the bodily fluid other than the dye component has a second amount of light absorptivity, wherein the first amount of light absorptivity is higher than the second amount of light absorptivity, and wherein the dye component has a third amount of light absorptivity in the second wavelength region higher than the second amount of light absorptivity;
determine a functional form which describes wavelength characteristics of a variation attributable to scattering that indicates an absorbance variation attributable to scattering of light in the bodily fluid, and is defined by one or more coefficients;
determine the one or more coefficients based on a first relational expression for the first observed value, involving a variation attributable to absorption that indicates an absorbance variation attributable to absorption of light in the bodily fluid, and a group of second relational expressions for the second observed values, not involving the variation attributable to absorption;
correct an absorbance measured at an arbitrary wavelength using a function where the determined one or more coefficients are applied to the determined functional form so as to reduce or eliminate at least the effects of the light scattering; and
determine, based on the corrected absorbance measured, an amount of concentration of the dye component in the bodily fluid.

2. The component measuring apparatus according to claim 1 , wherein correcting the absorbance measured at the arbitrary wavelength includes using the variation attributable to absorption so as to further reduce or eliminate the effects of the light absorption.

3. The component measuring apparatus according to claim 1 , wherein determining the one or more coefficients based on the first relational expression expressing that a sum of an absorbance corresponding to concentration of the dye component, the variation attributable to scattering, and the variation attributable to absorption equals the first observed value, and the group of second relational expressions expressing that a sum of the absorbance corresponding to concentration and the variation attributable to scattering equals the second observed values.

4. The component measuring apparatus according to claim 3 , wherein a constraint is added in determining the one or more coefficients, the constraint being an absorption spectral similarity regardless of concentrations of the dye component.

5. The component measuring apparatus according to claim 4 , wherein determining the functional form is based on a number of the one or more coefficients, the number being smaller than a number of the second observed values.

6. The component measuring apparatus according to claim 1 , wherein the functional form is any one of a polynomial function, a power function, and an exponential function.

7. The component measuring apparatus according to claim 1 , wherein the first observed value and the group of second observed values are acquired in wavelength intervals of at least 20 nm.

8. The component measuring apparatus according to claim 1 , wherein the bodily fluid is blood comprising hemoglobin, and the first observed value is acquired in the first wavelength region at 400 nm to 600 nm and the group of second observed values is acquired in the second wavelength region at 600 nm to 1000 nm.

9. The component measuring apparatus according to claim 1 , wherein the bodily fluid is blood, and the dye component is a component that develops color proportional to a glucose level in the blood.

10. A method for component measurement for measuring an analyte in a bodily fluid based on optical characteristics of a dye component contained in the bodily fluid before or after color reaction, comprising:
instructing, by a processor, an optical measurement system to direct light, via a light emitter, toward a test tip comprising the bodily fluid;
receiving, by the processor and via a light receiver of the optical measurement system, a signal corresponding to an amount of the light reflected from the test tip;
acquiring, by the processor and based on the received signal, a first observed value representing an absorbance at a specific wavelength in a first wavelength region in which a component of the bodily fluid other than the dye component has a first amount of light absorptivity;
acquiring, by the processor and based on the received signal, a group of second observed values representing absorbances at one or more different wavelengths in a second wavelength region in which the component of the bodily fluid other than the dye component has a second amount of light absorptivity, wherein the first amount of light absorptivity is higher than the second amount of light absorptivity, and wherein the dye component has a third amount of light absorptivity in the second wavelength region higher than the second amount of light absorptivity;
determining, by the processor, a functional form which describes wavelength characteristics of a variation attributable to scattering that indicates an absorbance variation attributable to scattering of light in the bodily fluid, and is defined by one or more coefficients;
determining, by the processor, the one or more coefficients based on a first relational expression for the first observed value, involving a variation attributable to absorption that indicates an absorbance variation attributable to absorption of light in the bodily fluid, and a group of second relational expressions for the second observed values, not involving the variation attributable to absorption;
correcting, by the processor, an absorbance measured at an arbitrary wavelength using a function where the determined one or more coefficients are applied to the determined functional form so as to reduce or eliminate at least the effects of the light scattering; and
determining, by the processor and based on the corrected absorbance measured, an amount of concentration of the dye component in the bodily fluid.

11. A program stored a non-transitory medium, the program comprising instructions for measuring an analyte in a bodily fluid based on optical characteristics of a dye component contained in the bodily fluid before or after color reaction, the instructions comprising:
instructions to instruct an optical measurement system to direct light, via a light emitter, toward a test tip comprising the bodily fluid;
instructions to receive, via a light receiver of the optical measurement system, a signal corresponding to an amount of the light reflected from the test tip;
instructions to acquire, based on the received

Assignees

• Terumo Corp

Inventors

• Ochiai Shouji
• Moriuchi Takeyuki
• Takinami Masao

Classifications

• C12Y101/03004

  Glucose oxidase (1.1.3.4) · CPC title

• G01N21/8483

  Investigating reagent band (test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04) · CPC title

• G01N21/78

  producing a change of colour · CPC title

• C12Q1/54

  involving glucose or galactose · CPC title

• G01N21/35

  using infrared light (G01N21/39 takes precedence) · CPC title