Compounds for increasing lipid synthesis and storage

Patent metadata

Field	Value
Publication number	US-10351883-B2
Application number	US-201615138066-A
Country	US
Kind code	B2
Filing date	Apr 25, 2016
Priority date	Apr 24, 2015
Publication date	Jul 16, 2019
Grant date	Jul 16, 2019

Abstract

This invention relates to methods for increasing lipid accumulation and lipid production in cells. Methods of producing biofuel from cells and preparing nutraceuticals comprising lipids produced according to a method provided herein are also provided.

First claim

What is claimed is:

1. A method of increasing lipid accumulation in an algal cell, comprising contacting the algal cell with an effective amount of a compound selected from the group consisting of:

or a salt thereof,
wherein the algal cell is selected from the group consisting of Chlamydomonas reinhardtii, Chlorella sorokiniana, Chlorella vulgaris , and Tetrachlorella altems.

2. A method of increasing lipid accumulation in an algal cell, comprising contacting the algal cell with an effective amount of a compound selected from the group consisting of:

or a salt thereof,
wherein the algal cell is selected from the group consisting of:
Chlamydomonas reinhardtii;
Chlorella sorokiniana;
Tetrachlorella alterans;
C. protothecoides;
C. vulgaris ; and
Nannochloropsis sp.

3. The method of claim 2 , wherein the algal cell is selected from the group consisting of Chlamydomonas reinhardtii, Chlorella sorokiniana, Chlorella vulgaris , and Tetrachlorella altems.

4. The method of claim 2 , wherein the compound is selected from the group consisting of:

or a salt thereof,
wherein the algal cell is selected from the group consisting of:
Chlamydomonas reinhardtii;
Chlorella sorokiniana;
Tetrachlorella alterans;
C. protothecoides;
C. vulgaris ; and
Nannochloropsis sp.

5. The method of claim 4 , wherein the algal cell is selected from the group consisting of Chlamydomonas reinhardtii, Chlorella sorokiniana, Chlorella vulgaris , and Tetrachlorella altems.

6. The method of claim 5 , wherein the compound is:

or a salt thereof.

7. The method of claim 5 , wherein the compound is:

or a salt thereof.

8. The method of claim 5 , wherein the compound is:

or a salt thereof.

Assignees

• Nutech Ventures

Inventors

• Dirusso Concetta
• Wase Nishikant

Classifications

• C12N1/38

  Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound (C12N1/34 takes precedence) · CPC title

• C12P7/6463

  obtained from glyceride producing microorganisms, e.g. single cell oil · CPC title

• C12P7/6409 Primary

  Fatty acids · CPC title

• C07D277/46

  by carboxylic acids, or sulfur or nitrogen analogues thereof · CPC title

• C07D231/40

  Acylated on said nitrogen atom · CPC title