Therapeutic compounds for pain and synthesis thereof
US-10040796-B2 · Aug 7, 2018 · US
Therapeutic compounds for pain and synthesis thereof
US10351565B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10351565-B2 |
| Application number | US-201816005366-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 11, 2018 |
| Priority date | Sep 4, 2015 |
| Publication date | Jul 16, 2019 |
| Grant date | Jul 16, 2019 |
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- Title
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- Abstract
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Abstract
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The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of making a compound of Formula 1, or stereoisomers thereof, wherein the method comprises reacting scopolamine with a reducing agent. 2. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 2, 3. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 3, 4. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 4, 5. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 5, 6. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 6.b, 7. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 7, 8. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 8, 9. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 9, 10. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 10, 11. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 11, 12. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 12, 13. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 12.a, 14. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 13, 15. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 14, 16. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 15, 17. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 16, 18. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 17, 19. The method of claim 1 , wherein the method further comprises reacting a compound of Formula 18, 20. A method of making a compound of Formula 1, or stereoisomers thereof, comprising reacting scopolamine with sodium borohydrate to form the compound of Formula 1. 21. The method of claim 1 , wherein the method comprises reacting scopolamine with a reducing agent and HCL in isopropyl alcohol. 22. The method of claim 20 , wherein the method comprises reacting scopolamine with sodium borohydrate and HCL in isopropyl alcohol.
Assignees
Inventors
Classifications
without antiinflammatory effect · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Centrally acting analgesics, e.g. opioids · CPC title
for peripheral neuropathies · CPC title
Oxygen atoms · CPC title
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Frequently asked questions
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- What does patent US10351565B2 cover?
- The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating c…
- Who is the assignee on this patent?
- Janssen Pharmaceutica Nv
- What technology area does this patent fall under?
- Primary CPC classification C07D471/18. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).