Simulation and diagnostic tool for sensorimotor diseases

Patent metadata

Field	Value
Publication number	US-10349859-B2
Application number	US-201715622953-A
Country	US
Kind code	B2
Filing date	Jun 14, 2017
Priority date	Jun 14, 2017
Publication date	Jul 16, 2019
Grant date	Jul 16, 2019

Abstract

Computational models and methods and systems of using the model to estimate variable time delay in the sensorimotor system of a subject are provided. The computational model can estimate variable time delays in the sensorimotor system, predict sensory states based on delayed sensory feedback, and/or control the system in real time. The subject can be a human or a primate. Simulation experiments can show how the model can explain a sensorimotor system's ability to compensate for delays during online learning and control.

First claim

What is claimed is:

1. A method of estimating time delay of a sensorimotor control system in a subject, comprising:
obtaining Jacobian matrices that respectively describe sensory states G(t) and motor control B(t) of the system;
obtaining a control vector u(t) describing neural motor commands from a neural network of the subject that dictate a desired motion or task of a muscle of the subject, the desired motion or task being described by a reference trajectory r(t);
computing a delayed sensory state of the system, described by vector x(t−τ) using the values of G(t), B(t), and u(t);
estimating, based on G(t), B(t), x(t−τ), and u(t), a time delay {circumflex over (τ)} of the system for performing the desired motion; and
improving a condition of the subject by stimulating sensory neurons of the subject through transmission, via a transmitting device, of a visual stimulation signal to the sensory neurons of the subject, the visual stimulation signal being generated based upon the estimated time delay, and the visual stimulation signal increasing a speed of the sensory neurons of the subject,
the computing of the delayed sensory state vector x(t−τ) comprising the use of the following equation:

x
⁡

(

t
-
τ

)

=

G
⁡

(

t
-
τ

)

⁢

x
0

+

G
⁡

(

t
-
τ

)

⁢

∫
0

t
-
τ

⁢

G

-
1

⁡

(
s
)

⁢

B
⁡

(
s
)

⁢

u
⁡

(
s
)

⁢
ds

where x 0 is an initial sensory state, and
where t is time and τ is the actual time delay.

2. A method of estimating time delay of a sensorimotor control system in a subject, comprising:
obtaining Jacobian matrices that respectively describe sensory states G(t) and motor control B(t) of the system;
obtaining a control vector u(t) describing neural motor commands from a neural network of the subject that dictate a desired motion or task of a muscle of the subject, the desired motion or task being described by a reference trajectory r(t);
computing, based on G(t), B(t), and u(t), a delayed sensory state of the system, described by vector x(t−τ);
estimating a time delay {circumflex over (τ)} of the system for performing the desired motion; and
improving a condition of the subject by stimulator sensor neurons of the subject through transmission, via a transmitting device, of a visual stimulation signal to the sensory neurons of the subject, the visual stimulation signal being generated based upon the estimated time delay, and the visual stimulation signal increasing a speed of the sensory neurons of the subject,
the estimating of the time delay comprising the use of the following equation:

d
⁢

⁢

τ
^

d
⁢

⁢
t

=

ηζ
⁢

∂

G
⁡

(

t
-

τ
^

)

∂

τ
^

⁡

[

x
0

+

∫
0

t
-

τ
^

⁢

(

B
⁡

(
s
)

/

G
⁡

(
s
)

Assignees

• Sargolzaei Arman
• Abdelghani Mohamed
• Yen Kang K
• Sargolzaei Saman
• The Florida International Univ Board Of Trustees

Inventors

• Sargolzaei Arman
• Abdelghani Mohamed
• Yen Kang K
• Sargolzaei Saman

Classifications

• A61B5/378 Primary

  Visual stimuli · CPC title

• A61B5/0476 Primary

  Human Necessities · mapped topic

• G16H30/00

  ICT specially adapted for the handling or processing of medical images (computed tomography A61B6/03) · CPC title

• A61B5/6868

  Brain · CPC title

• A61B5/7246

  using correlation, e.g. template matching or determination of similarity · CPC title