Terahertz wave spectrometry system

Patent metadata

Field	Value
Publication number	US-10345150-B2
Application number	US-201715497181-A
Country	US
Kind code	B2
Filing date	Apr 25, 2017
Priority date	May 19, 2016
Publication date	Jul 9, 2019
Grant date	Jul 9, 2019

Abstract

A terahertz wave spectrometry system that is capable of identifying analyzing target molecules contained in an analyte even if the analyte contains water, by activating a water remover to remove water according a comparison of absorption spectrums so that water in the analyte is easily removed without causing the analyzing target molecules to disappear due to decomposition or denaturation.

First claim

What is claimed is:

1. A terahertz wave spectrometry system comprising:
a terahertz wave emitter configured to emit a terahertz wave to irradiate a test substance with the terahertz wave;
a light receiver configured to receive an absorbance of a terahertz wave transmitted through or reflected from the test substance; and
a water remover configured to remove water contained in the test substance; and
a signal processor,
wherein the signal processor is configured to:
output an irradiation signal instructing the terahertz wave emitter to irradiate the test substance with the terahertz wave while increasing or decreasing a frequency x of the terahertz wave;
acquire an intensity of the terahertz wave received by the light receiver;
calculate a function f1( x ) of a first absorption spectrum representing the absorbance with respect to the frequency x, on the basis of an intensity of the terahertz wave emitted by the terahertz wave emitter and the intensity of the terahertz wave received by the light receiver;
output a drying signal to the water remover to activate the water remover when an absorbance at a specified frequency x1 of the first absorption spectrum is equal to or larger than a predetermined value;
output an irradiation signal instructing the terahertz wave emitter to irradiate the test substance again with the terahertz wave while increasing or decreasing the frequency x of the terahertz wave;
acquire an intensity of the terahertz wave received by the light receiver again;
calculate a function f2( x ) of a second absorption spectrum representing the absorbance with respect to the frequency x, on the basis of an intensity of the terahertz wave emitted again by the terahertz wave emitter and the intensity of the terahertz wave received again by the light receiver; and
output an output reducing signal to the water remover to reduce an output of the water remover when a height of an absorption peak at a frequency x1 of the second absorption spectrum is smaller than a height of an absorption peak at the frequency x1 of the first absorption spectrum.

2. The terahertz wave spectrometry system according to claim 1 , wherein the signal processor is further configured to output the output reducing signal to the water remover to reduce the output of the water remover when a frequency at an absorption peak of the second absorption spectrum is different from a frequency at an absorption peak of the first absorption spectrum.

3. The terahertz wave spectrometry system according to claim 1 , wherein the signal processor is further configured to output the output reducing signal to the water remover to reduce the output of the water remover when a formula (III) shown below is satisfied:
“reference difference”≥“comparison difference”  (III)

where:
“reference difference”=“a height of an absorption peak at a frequency x1 of the first absorption spectrum”−“a height of an absorption peak at a frequency x1 of the second absorption spectrum”;
“comparison difference”=“an absorbance at a frequency x2 of the first absorption spectrum”−“an absorbance at a frequency x2 of the second absorption spectrum”; and
x1<x2.

4. A method of removing water contained in a test substance, comprising:
(a) irradiating a test substance with a terahertz wave using a terahertz wave emitter while increasing or decreasing a frequency x of the terahertz wave;
(b) receiving the terahertz wave which has been transmitted through or reflected from the test sample with a light receiver;
(c) calculating a function f1( x ) of a first absorption spectrum representing the absorbance with respect to the frequency x, on the basis of an intensity of the terahertz wave emitted by the terahertz wave emitter and the intensity of the terahertz wave received by the light receiver;
(d) determining an absorbance at a specified frequency x1 of the first absorption spectrum is equal to or larger than a predetermined value;
(e) outputting a drying signal to a water remover to activate the water remover based after step (d);
(f) drying the test sample with the activated water remover based on the absorbance at the specified frequency x1 of the first absorption spectrum;
(g) irradiating the test substance with the terahertz wave again using the terahertz wave emitter while increasing or decreasing the frequency x of the terahertz wave;
(h) receiving the terahertz wave which has been transmitted through or reflected from the test sample with a light receiver again;
calculating a function f2( x ) of a second absorption spectrum representing the absorbance with respect to the frequency x, on the basis of an intensity of the terahertz wave emitted again by the terahertz wave emitter and the intensity of the terahertz wave received again by the light receiver;
(i) determining that the height of an absorption peak at the frequency x1 of the second absorption spectrum is smaller than a height of an absorption peak at the frequency x1 of the first absorption spectrum; and
(j) after step (i) outputting an output reducing signal to the water remover based on the height of the absorption peak at the frequency x1 of the second absorption spectrum.

Assignees

• Panasonic Ip Man Co Ltd

Inventors

• Fujihara Seiji
• Naito Yasuyuki
• Tomiyama Morio

Classifications

• G01N21/49

  within a body or fluid · CPC title

• G01J3/4338

  Frequency modulated spectrometry · CPC title

• G01J2003/425

  Reflectance · CPC title

• G01J3/42 Primary

  Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry (beam switching arrangements G01J3/08) · CPC title

• G01N21/3563

  for analysing solids; Preparation of samples therefor · CPC title