Magnesium-zinc-calcium alloy and method for producing implants containing the same

Patent metadata

Field	Value
Publication number	US-10344365-B2
Application number	US-201314396012-A
Country	US
Kind code	B2
Filing date	Jun 25, 2013
Priority date	Jun 26, 2012
Publication date	Jul 9, 2019
Grant date	Jul 9, 2019

Abstract

A magnesium alloy includes <3% by weight of Zn, ≤0.6% by weight of Ca, with the rest being formed by magnesium containing impurities, which favor electrochemical potential differences and/or promote the formation of intermetallic phases, in a total amount of no more than 0.005% by weight of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P, wherein the alloy contains elements selected from the group of rare earths with the atomic number 21, 39, 57 to 71 and 89 to 103 in a total amount of no more than 0.002% by weight.

First claim

The invention claimed is:

1. A biodegradable implant comprising:
a magensium alloy having improved mechanical and electromechanical properties, comprising 0.1 to 1.6% by weight of Zn, 0.001 to 0.5% by weight of Ca, with the rest being high-purity vacuum distilled magnesium containing impurities, which favor electromechanical potential differences and/or promote the formation of intermetallic phases, in a total amount of no more than 0.005% by weight of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P, wherein the alloy contains elements selected from the group of rare earths with the atomic number 21, 39, 57 to 71 and 89 to 103 in a total amount of no more than 0.002% by weight;
wherein a ratio of the content of Zn to the content of Ca is no more than 3, wherein the alloy contains an intermetallic phase Ca 2 Mg 6 Zn 3 and/or Mg 2 Ca in a volume fraction of close to 0 to 2%, and wherein the content of Zr is no more than 0.0003% by weight, and wherein the biodegradable implant has a strength of >275 MPa, and a ratio yield point of <0.8, wherein the difference between strength and yield point is >50 MPa.

2. The implant as claimed in claim 1 , wherein the alloy does not contain an intermetallic phase MgZn.

3. The implant as claimed in claim 1 , wherein the content of Ca is 0.2 to 0.4% by weight, and the alloy contains the intermetallic phase Mg 2 Ca.

4. The implant as claimed in claim 1 , wherein the ratio of the content of Zn to the content of Ca is no more than 1.

5. The implant as claimed in claim 1 , wherein individual impurities contributing to the total sum of the impurities are present in the following amounts in % by weight: Fe ≤<0.0005; Si ≤0.0005; Mn ≤0.0005; Co ≤0.0002; Ni ≤0.0002; Cu ≤0.0002; Al ≤0.001; Zr ≤0.0003; P ≤0.0001.

6. The implant as claimed in claim 1 , wherein a combination of the impurity elements Fe, Si, Mn, Co, Ni, Cu and Al totals no more than 0.004% by weight, the content of Al is no more than 0.001% by weight, and/or the content of Zr is no more than 0.0003% by weight.

7. The implant as claimed in claim 1 , wherein individual elements from the group of rare earths total no more than 0.001% by weight.

8. The implant as claimed in claim 1 , wherein the alloy has a fine-grain microstructure with a grain size of no more than 5.0 μm without considerable electrochemical potential differences between the individual matrix phases.

9. The implant as claimed in claim 1 , wherein the alloy contains an intermetallic phase Ca 2 Mg 6 Zn 3 and/or Mg 2 Ca and the intermetallic phase is as noble as the matrix phase or is less noble than the matrix phase.

10. The implant as claimed in claim 9 , wherein precipitates have a size of no more than 2.0 μm and are distributed dispersely at the grain boundaries or inside the grain.

11. The implant as claimed in claim 1 , wherein the content of Ca is 0.001 to 0.4% by weight.

12. The implant as claimed in claim 11 , wherein the content of Ca is 0.1 to 0.4% by weight.

13. The implant as claimed in claim 12 , wherein a ratio of the content of Zn to the content of Ca is no more than 1.

14. The implant as claimed in claim 1 , wherein individual impurities contributing to the total sum of the impurities are present in the following amounts in % by weight: Fe ≤0.0005; Si ≤0.0005; Mn ≤0.0005; Co ≤0.0002; Ni ≤0.0002; Cu ≤0.0002; Al ≤0.001; Zr ≤0.0001; P ≤0.0001.

15. The implant as claimed in claim 1 , wherein a combination of the impurity elements Fe, Si, Mn, Co, Ni, Cu and Al totals no more than 0.001% by weight, the content of Al is no more than 0.001% by weight, and/or the content of Zr is no more than 0.0001% by weight.

16. The implant as claimed in claim 1 , wherein individual elements from the group of rare earths total no more than 0.0003% by weight.

17. The implant as claimed in claim 16 , wherein individual elements from the group of rare earths total no more than 0.0001% by weight.

18. The implant as claimed in claim 1 , wherein the alloy has a fine-grain microstructure with a grain size of no more than 3.0 μm without considerable electrochemical potential differences between the individual matrix phases.

19. The implant as claimed in claim 1 , wherein the alloy has a fine-grain microstructure with a grain size of no more than 1.0 μm.

20. The implant as claimed in claim 1 , having a strength of >300 MPa, a yield point of >225 MPa, and a ratio yield point of <0.75, wherein the difference between strength and yield point is >100 MPa, and the mechanical asymmetry is <1.25.

21. The implant of claim 1 wherein the content of Ca is 0.001 to 0.2% by weight.

22. The implant of claim 1 wherein the content of Ca is 0.1 to 0.2% by weight.

23. A biodegradable implant comprising:
a magnesium alloy having improved mechanical and electromechanical properties, comprising 0.1 to 1.6% by weight of Zn, 0.001 to 0.5% by weight of Ca, with the rest being formed by magnesium containing impurities, which favor electrochemical potential differences and/or promote the formation of intermetallic phases, in a total amount of no more than 0.005% by weight of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P, wherein the alloy contains elements selected from the group of rare earths with the atomic number 21, 39, 57 to 71 and 89 to 103 in a total amount of no more than 0.002% by weight;
wherein the ratio of the content of Zn to the content of Ca is no more than 3, wherein the alloy contains an intermetallic phase Ca 2 Mg 6 Zn 3 and/or Mg 2 Ca in a volume fraction of close to 0 to 2%, and wherein the content of Zr is no more than 0.0003% by weight, and wherein the biodegradable implant has a strength of >300 MPa, and a ratio yield point of <0.75, wherein the difference between strength point and yield point is >50 MPa.

24. The implant of claim 23 wherein the ratio of the content of Zn to the content of Ca is no more than 1.

Assignees

• Biotronik Ag

Inventors

• Mueller Heinz
• Uggowitzer Peter
• Loeffler Joerg

Classifications

• C22F1/06 Primary

  of magnesium or alloys based thereon · CPC title

• C22C23/04

  with zinc or cadmium as the next major constituent · CPC title