Pesticidal compositions and processes related thereto
US-2015353477-A1 · Dec 10, 2015 · US
Processes for the convergent synthesis of calicheamicin derivatives
US10343989B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10343989-B2 |
| Application number | US-201715719504-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 28, 2017 |
| Priority date | Feb 21, 2006 |
| Publication date | Jul 9, 2019 |
| Grant date | Jul 9, 2019 |
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- Title
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- Abstract
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Abstract
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This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
First claim
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What is claimed is: 1. A compound selected from: butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutoxy]phenyl]ethylidene]hydrazide; and butanoic acid,3-mercapto-3-methyl-,2-[(E)-1[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide. 2. A sodium salt of butanoic acid,3-mercapto-3 -methyl -,2-[(E)-1-[4-[4-[(2,5 -dioxo-1-pyrrolidinyl)oxy] -4-oxobutoxy]phenyl]ethylidene]hydrazide. 3. A sodium salt of butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide. 4. The compound of claim 1 , wherein the compound is butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutoxy]phenyl]ethylidene]hydrazide. 5. The compound of claim 1 , wherein the compound is butanoic acid,3-mercapto-3-methyl-,2-[(E)-1-[4-(4-hydroxy-4-oxobutoxy)phenyl]ethylidene]hydrazide.
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Classifications
Antineoplastic agents · CPC title
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide · CPC title
containing three or more hetero rings · CPC title
Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems · CPC title
with hetero atoms directly attached to the ring nitrogen atom · CPC title
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- What does patent US10343989B2 cover?
- This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
- Who is the assignee on this patent?
- Wyeth Llc
- What technology area does this patent fall under?
- Primary CPC classification C07C323/60. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).