Injectable, biodegradable bone cements and methods of making and using same

Patent metadata

Field	Value
Publication number	US-10342893-B2
Application number	US-201314375927-A
Country	US
Kind code	B2
Filing date	Jan 31, 2013
Priority date	Jan 31, 2012
Publication date	Jul 9, 2019
Grant date	Jul 9, 2019

Abstract

Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. A bone cement composition includes a powder comprising a basic source of calcium, magnesium, or strontium, a setting solution comprising H3PO4 and a buffer, and a biocompatible polymer that is incorporated into the setting solution. The powder is mixed with the setting solution to form a bone cement paste that either (a) sets into a hardened mass, or (b) is irradiated with electromagnetic radiation to form dry powders, the dry powders then being mixed with a second setting solution to form a radiation-assisted bone cement paste that sets into a hardened mass.

First claim

What is claimed is:

1. A bone cement composition comprising:
a magnesium phosphate comprising newberyite; a biocompatible polymer; and
silica sol;
wherein the bone cement composition is in the form of an injectable paste or a putty.

2. The bone cement of claim 1 , wherein the biocompatible polymer comprises chitosan.

3. The bone cement of claim 1 , wherein the biocompatible polymer is surface-phosphorylated.

4. A bone cement composition comprising:
a magnesium phosphate comprising newberyite; and
silica sol;
wherein the bone cement composition is in the form of an injectable paste or a putty.

5. The bone cement composition of claim 4 , further comprising an additive selected from the group consisting of: proteins, osteoinductive materials, osteoconductive materials, X-ray opacifying agents, medicaments, supporting or strengthening filler materials, crystal growth adjusters, viscosity modifiers, pore-forming agents, antibiotics, antiseptics, growth factors, chemotherapeutic agents, bone resorption inhibitors, color change agents, immersing liquids, carboxylates, carboxylic acids, α-hydroxyl acids, collagen, pyrophosphates, sulfates, and metallic ions.

6. The bone cement composition of claim 4 , further comprising a nonaqueous extender comprising glycerine and/or propylene glycol, wherein the bone cement composition is in the form of a putty.

7. A bone cement composition comprising:
a magnesium phosphate comprising newberyite; and
silica;
wherein the bone cement composition is in the form of a hardened mass.

Assignees

• Univ Toledo

Inventors

• Bhaduri Sarit B
• Zhou Huan
• Agarwal Anand K
• Goel Vijay K

Classifications

• A61K6/864

  Phosphate cements (apatite A61K6/838) · CPC title

• A61K6/898

  Polysaccharides · CPC title

• A61K6/74

  comprising phosphorus-containing compounds · CPC title

• A61L27/32

  Phosphorus-containing materials, e.g. apatite · CPC title

• A61L2420/04

  Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases · CPC title