Robust dual echo Dixon imaging with flexible echo times

Patent metadata

Field	Value
Publication number	US-10338174-B2
Application number	US-201615352420-A
Country	US
Kind code	B2
Filing date	Nov 15, 2016
Priority date	Feb 11, 2016
Publication date	Jul 2, 2019
Grant date	Jul 2, 2019

Abstract

A method for creating a first MRI image and a second MRI image is provided. A first echo is read out. A second echo is read out. The first echo readout is used to generate a first image set, with each image pixel being a first linear combination of the first species and the second species. The second echo readout is used to generate a second image set, with each image pixel being a second linear combination of the first species and the second species. The first image set and second image set are combined to obtain a first combined image containing only the first species and a second combined image containing only the second species, comprising combining the first image set and the second image set to generate two pairs of solutions and using a mathematical optimization to choose a correct pair of solutions.

First claim

What is claimed is:

1. A method for creating a first MRI image of an object in an MRI system indicating a first species and a second MRI image of the object indicating a second species, comprising:
applying, through the MRI system, a radio frequency (RF) excitation of the object;
reading out through the MRI system a first echo from the object;
reading out through the MRI system a second echo of the object;
using the first echo readout to generate a first image set, with each image pixel of a plurality of image pixels being a first linear combination of the first species and the second species;
using the second echo readout to generate a second image set, with each image pixel being a second linear combination of the first species and the second species;
combining the first image set and second image set to obtain a first combined image containing only the first species and a second combined image containing only the second species, comprising:
combining the first image set and the second image set at each image pixel to generate two solution pairs at all of the image pixels of the plurality of pixels, wherein for each image pixel the two solution pairs have a first solution pair that represents the first species and the second species and a second solution pair that represents the first species and the second species, wherein at each image pixel the first species and second species are calculated together as a pair from the first image set and the second image set to yield the two solution pairs; and
using a mathematical optimization of an image region to choose for each image pixel either the first solution pair or the second solution pair that represents the first species and the second species for all of the image pixels.

2. The method, as recited in claim 1 , wherein the mathematical optimization is an optimization of all the image pixels.

3. The method, as recited in claim 2 , wherein the mathematical optimization is a binary quadratic optimization.

4. The method, as recited in claim 3 , wherein the mathematical optimization optimizes homogeneity of the magnetic field of the MRI system.

5. The method, as recited in claim 4 , further comprising:
reading out through the MRI system a plurality of first echoes from the object;
reading out through the MRI system a plurality of second echoes from the object, wherein the first image set further comprises readout from the plurality of first echoes and the second image set further comprises readout from the plurality of second echoes.

6. The method, as recited in claim 5 , wherein the mathematical optimization provides binary constraints.

7. The method, as recited in claim 6 , wherein the mathematical optimization optimizes an objective function in the form of f(x)=X T VX, wherein X is a binary vector and a value of each entry in X can only be 0 or 1, and V is a square matrix and a value of each entry in V represents the homogeneity of the magnetic field between two image pixels.

8. The method, as recited in claim 7 , wherein the mathematical optimization satisfies a MRI signal equation between the first image set and the second image set.

9. The method, as recited in claim 1 , wherein the mathematical optimization is a binary quadratic optimization.

10. The method, as recited in claim 1 , wherein the mathematical optimization optimizes homogeneity of the magnetic field of the MRI system.

11. The method, as recited in claim 1 , further comprising:
reading out through the MRI system a plurality of first echoes from the object;
reading out through the MRI system a plurality of second echoes from the object, wherein the first image set further comprises readout from the plurality of first echoes and the second image set further comprises readout from the plurality of second echoes.

12. The method, as recited in claim 1 , wherein the mathematical optimization provides binary constraints.

13. A method for creating a first MRI image of an object in an MRI system indicating a first species and a second MRI image of the object indicating a second species, comprising:
applying, through the MRI system, a radio frequency (RF) excitation of the object;
reading out through the MRI system a first echo from the object;
reading out through the MRI system a second echo of the object;
using the first echo readout to generate a first image set, with each image pixel of a plurality of image pixels being a first linear combination of the first species and the second species;
using the second echo readout to generate a second image set, with each image pixel being a second linear combination of the first species and the second species;
combining the first image set and second image set to obtain a first combined image containing only the first species and a second combined image containing only the second species, comprising:
combining the first image set and the second image set at each image pixel to generate two solution pairs at all of the image pixels of the plurality of pixels, wherein for each image pixel the two solution pairs have a first solution pair that represents the first species and the second species and a second solution pair that represents the first species and the second species, wherein at each image pixel the first species and second species are calculated together as a pair from the first image set and the second image set to yield the two solution pairs; and
using a mathematical optimization of an image region to choose for each image pixel either the first solution pair or the second solution pair that represents the first species and the second species for all of the image pixels, wherein the mathematical optimization optimizes an objective function in the form of f(x)=X T VX, wherein X is a binary vector and a value of each entry in X can only be 0 or 1, and V is a square matrix and a value of each entry in V represents the homogeneity of the magnetic field between two image pixels.

14. The method, as recited in claim 1 , wherein the mathematical optimization satisfies a MRI signal equation between the first image set and the second image set.

15. A method for creating a first MRI image of an object in an MRI system indicating a first species and a second MRI image of the object indicating a second species, comprising:
applying, through the MRI system, a plurality of radio frequency (RF) excitations of the object;
reading out through the MRI system a plurality of first echoes from the object;
reading out through the MRI system a plurality of second echoes of the object;
using the readout of plurality of first echoes to generate a first image set, with each image pixel of a plurality of image pixels of the first image set being a first linear combination of the first species and the second species;
using the readout of the plurality of second echoes to generate a second image set, with each image pixel of the plurality of image pixels of the second image set being a second linear combination of the first species and the second species;
combining the first image set and second image set to obtain a first combined image containing only the first species and a second combined image containing only the second species, comprising:
combining the first image set and the second image set at each image pixel to generate two solution pairs at all of the image pixels of the plurality of pixels, wherein for each image pixel the two solution pairs have a first solution pair that represents the first species and the second species and a second solution pair that represents the first species and the second species, wherein at each image pixel the first sp

Assignees

• Univ Leland Stanford Junior
• The Board Of Trustees Of The Leland Stanford Junior Univesity

Inventors

• Zhang Tao
• Chen Yuxin
• Pauly John M
• Vasanawala Shreyas S

Classifications

• G01R33/5611

  Parallel magnetic resonance imaging, e.g. sensitivity encoding [SENSE], simultaneous acquisition of spatial harmonics [SMASH], unaliasing by Fourier encoding of the overlaps using the temporal dimension [UNFOLD], k-t-broad-use linear acquisition speed-up technique [k-t-BLAST], k-t-SENSE (structural details of arrays of sub-coils G01R33/3415) · CPC title

• G01R33/56325

  Cine imaging · CPC title

• G01R33/5601

  involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent · CPC title

• G01R33/56308

  Characterization of motion or flow; Dynamic imaging · CPC title

• G01R33/4828 Primary

  Resolving the MR signals of different chemical species, e.g. water-fat imaging · CPC title