Cyclic carbonate monomer containing double iodine, biodegradable polymer prepared thereby and use

Patent metadata

Field	Value
Publication number	US-10336720-B2
Application number	US-201615550787-A
Country	US
Kind code	B2
Filing date	Feb 12, 2016
Priority date	Feb 13, 2015
Publication date	Jul 2, 2019
Grant date	Jul 2, 2019

Abstract

The disclosure relates to a cyclic carbonate monomer containing double iodine, a biodegradable polymer prepared thereby and use. The polymer can be obtained by ring-opening polymerization of the cyclic carbonate monomer containing double iodine, without affecting the ring-opening polymerization and without a protection and deprotection process. The polymer which is obtained by ring-opening polymerization of the cyclic carbonate monomer of the present disclosure can be assembled into a nano-vesicle and a micelle as a drug carrier, a biological tissue scaffold or a CT contrast media.

First claim

What is claimed is:

1. A biodegradable polymer containing a functional group of double iodine in the side chain, which includes cyclic carbonate monomer containing double iodine, wherein the biodegradable polymer containing a functional group of double iodine is polymerized of cyclic carbonate monomer containing double iodine by one of the following steps:
(1) homopolymerize by cyclic carbonate monomer containing double iodine; or
(2) cyclic carbonate monomer containing double iodine has copolymerization with cyclic carbonate containing double sulfur or trimethylene cyclic carbonate;
said cyclic carbonate monomer containing double iodine is

the molecular weight of said biodegradable polymer containing a functional group of double iodine in the side chain is 3-500 kDa;
said biodegradable polymer containing a functional group of double iodine in the side chain has a polydispersity index (PDI) of 1.30 to 1.53; and
said biodegradable polymer containing a functional group of double iodine in the side chain forms nano-vesicles after dialysis.

2. The biodegradable polymer containing a functional group of double iodine in the side chain according to claim 1 , wherein the amount of iodine in the molecular chain of aforesaid biodegradable polymer containing a functional group of double iodine in the side chain is 5%-65%.

3. The biodegradable polymer containing a functional group of double iodine in the side chain according to claim 1 , wherein the cyclic carbonate monomer containing double iodine is polymerized in the presence of polyethylene glycol, ethylene glycol, isopropanol or propynol as the initiator and zinc bis [bis(trimethylsilyl) amide] as the catalyst.

4. The biodegradable polymer containing a functional group of double iodine in the side chain according to claim 1 , wherein when the cyclic carbonate monomer containing double iodine is polymerized, the polymerization temperature is 40° C. and the polymerization time is 24-72 hours.

Assignees

• Univ Soochow

Inventors

• Zhong Zhiyuan
• Zou Yan
• Wei Yaohua
• Meng Fenghua

Classifications

• C08L67/04

  Polyesters derived from hydroxycarboxylic acids, e.g. lactones (C08L67/06 takes precedence) · CPC title

• A61K49/0442

  Polymeric X-ray contrast-enhancing agent comprising a halogenated group · CPC title

• C08G64/025

  containing sulfur · CPC title

• C08G64/30

  using carbonates · CPC title

• C07D319/06 Primary

  not condensed with other rings · CPC title