Multitube esophageal brachytherapy catheter

Patent metadata

Field	Value
Publication number	US-10335609-B2
Application number	US-201514847927-A
Country	US
Kind code	B2
Filing date	Sep 8, 2015
Priority date	Mar 12, 2013
Publication date	Jul 2, 2019
Grant date	Jul 2, 2019

Abstract

A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a catheter body with a proximal portion, a distal portion, and a longitudinally oriented lumen therebetween. The system further includes an expansion device disposed about at least a portion of the catheter body and having an expanded configuration and a non-expanded configuration. The system also includes a plurality of tubes disposed about at least a portion of the expansion device. Each of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.

First claim

What is claimed is:

1. A system for delivery of radiation to a target portion of a native tissue, the system comprising:
a catheter comprising a catheter body having a proximal portion, a distal portion, and a longitudinally oriented lumen therebetween;
an expansion device disposed about at least a portion of the catheter body and having an expanded configuration and a non-expanded configuration;
an anchor balloon disposed about the catheter body distal to the expansion device and having an inflated configuration and a deflated configuration, the anchor balloon having a curved outer surface in an inflated configuration;
a plurality of tubes disposed about at least a portion of the expansion device and disposed only part-way along the longitudinal length of the anchor balloon along the curved outer surface, each of the plurality of tubes being configured to selectively guide exposure of a radiation source to the target portion of the native tissue.

2. The system of claim 1 , wherein the distal portion of the catheter body comprises a tapered tip having a closed distal end.

3. The system of claim 2 , wherein the longitudinally oriented lumen has a longitudinal axis and the distal portion of the catheter body defines a lateral port non-concentric with the longitudinal axis.

4. The system of claim 1 , wherein a distal section of the plurality of tubes is deflected radially when the anchor balloon assumes an inflated configuration.

5. The system of claim 1 , further comprising a sheath disposed at least partially about the plurality of tubes.

6. A method of selectively delivering radiation to a target portion of tissue at the gastroesophageal junction comprising:
inserting a radiation delivery system into a patient's body, the radiation delivery system comprising:
a catheter comprising a catheter body having a proximal portion, a distal portion and a longitudinally oriented lumen extending therebetween;
an expansion device disposed about at least a portion of the catheter body;
an anchor balloon disposed about the catheter body distal to the expansion device, the anchor balloon having a curved outer surface in an inflated configuration;
a plurality of tubes disposed about at least a portion of the expansion device, each of the plurality of tubes being configured to selectively guide exposure of a radiation source to the target portion of the tissue at the gastroesophageal junction;

inflating the anchor balloon to position the distal ends of the plurality of tubes in close proximity to the target portion of the tissue at the gastroesophageal junction, the plurality of tubes disposed only part-way along the longitudinal length of the anchor balloon along the curved outer surface;
adjusting the radial position of the plurality of tubes by expanding the expansion device to radially move the plurality of tubes in closer proximity to the gastroesophageal junction or the target portion of the tissue at the gastroesophageal junction;
inserting a radiation source into one or more of the plurality of tubes; and
selectively applying radiation to the target portion of the tissue at the gastroesophageal junction.

7. The method of claim 6 , wherein the anchor balloon, in an inflated configuration, dilates the native tissue.

8. The method of claim 6 , wherein the anchor balloon, in an inflated configuration secures the position of the catheter within the native tissue.

9. The method of claim 6 , wherein the anchor balloon, in an inflated configuration, repositions the plurality of tubes in closer proximity to the target portion of the native tissue.

10. The method of claim 6 , further comprising inserting a mouth guard in the patient's mouth prior to inserting the radiation delivery system.

11. The method of claim 6 , wherein the target portion of the tissue is a tumor.

12. The method of claim 6 , further comprising:
completing computer tomography (CT) and/or magnetic resonance imaging (MRI) with the radiation delivery system in place for radiation treatment planning; and
using forward or inverse planning to deliver radiation to the target portion of the tissue.

Assignees

• Cleveland Clinic Found

Inventors

• Greskovich Jr John
• Gao Shengqiang

Classifications

• A61N2005/1094

  Shielding, protecting against radiation · CPC title

• A61N2005/1004

  having expandable radiation sources · CPC title

• A61N2005/1003

  having means for centering a radioactive source within the lumen, e.g. balloons · CPC title

• A61N2005/1005

  with asymmetrical radiation pattern · CPC title

• A61N2005/1018

  with multiple channels for guiding radioactive sources · CPC title