Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl) amino) caprylic acid
US-2018360918-A1 · Dec 20, 2018 · US
Compositions comprising a delivery agent and preparation thereof
US10335369B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10335369-B2 |
| Application number | US-201314386218-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 15, 2013 |
| Priority date | Mar 22, 2012 |
| Publication date | Jul 2, 2019 |
| Grant date | Jul 2, 2019 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The invention relates to granules and pharmaceutical compositions comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant obtained by mixing hereof for more than 5 minutes prior to granulation as well as processes for their preparation and use thereof in medicine.
First claim
Opening claim text (preview).
The invention claimed is: 1. A process of producing by dry granulation a granule comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant, wherein said process comprises the steps: a) mixing said salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and said lubricant for more than 5 minutes; and b) optionally roller compacting the mixture of step a, wherein the granule produced by said process does not contain a pharmaceutically active agent. 2. A process according to claim 1 , wherein the duration of said mixing in step a is at least 20 minutes. 3. A process according to claim 1 , wherein the amount of said lubricant is at least 0.25% (w/w) of said composition. 4. The process according to claim 3 , wherein the amount of said lubricant is at least 2.0% (w/w) of said composition. 5. The process according to claim 4 , wherein the amount of said lubricant is less than 10.0% (w/w) of said composition. 6. The process according to claim 5 , wherein the lubricant is magnesium stearate.
Assignees
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Classifications
for hyperglycaemia, e.g. antidiabetics · CPC title
Anorexiants; Antiobesity agents · CPC title
Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title
Processes · CPC title
- A61K9/1617Primary
Organic compounds, e.g. phospholipids, fats · CPC title
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- What does patent US10335369B2 cover?
- The invention relates to granules and pharmaceutical compositions comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant obtained by mixing hereof for more than 5 minutes prior to granulation as well as processes for their preparation and use thereof in medicine.
- Who is the assignee on this patent?
- Novo Nordisk As
- What technology area does this patent fall under?
- Primary CPC classification A61K9/1617. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).