Brain tissue classification

Patent metadata

Field	Value
Publication number	US-10331981-B2
Application number	US-201615564263-A
Country	US
Kind code	B2
Filing date	Apr 25, 2016
Priority date	Apr 30, 2015
Publication date	Jun 25, 2019
Grant date	Jun 25, 2019

Abstract

A system and method are provided for brain tissue classification, which involves applying an automated tissue classification technique to an image of a brain based on a prior probability map, thereby obtaining a tissue classification map of the brain. A user is enabled to, using a user interaction subsystem, provide user feedback which is indicative of a) an area of misclassification in the tissue classification map and b) a correction of the misclassification. The prior probability map is then adjusted based on the user feedback to obtain an adjusted prior probability map, and the automated tissue classification technique is re-applied to the image based on the adjusted prior probability map. An advantage over a direct correction of the tissue classification map may be that the user does not need to indicate the area of misclassification or the correction of the misclassification with a highest degree of accuracy. Rather, it may suffice to provide an approximate indication thereof.

First claim

The invention claimed is:

1. A system for brain tissue classification, comprising:
an image data interface for accessing an image of a brain of a patient;
a processor configured to apply an automated tissue classification technique to the image based on a prior probability map, the prior probability map being registered to the image and being indicative of a probability of a particular location in the brain belonging to a particular brain tissue class, the automated tissue classification technique providing as output a tissue classification map of the brain of the patient;
a user interaction subsystem configured to enable the user to indicate a point in the area of misclassification, thereby obtaining a user-indicated point, comprising:
i) a display output for displaying the tissue classification map on a display,
ii) a user device input for receiving input commands from a user device operable by a user, wherein the input commands represent user feedback which is indicative of a) an area of misclassification in the tissue classification map and b) a correction of the misclassification, the user feedback indicating a point in the area of misclassification, thereby obtaining a user-indicated point; wherein the processor is configured to:
determine a boundary of the area of misclassification based on the user-indicated point,
adjust the prior probability map based on the user feedback, thereby obtaining an adjusted prior probability map, and
re-apply the automated tissue classification technique to the image based on the adjusted prior probability map.

2. The system according to claim 1 , wherein the user interaction subsystem is configured to enable the user to indicate the correction of the misclassification by manually specifying a brain tissue class, thereby obtaining a user-specified brain tissue class.

3. The system according to claim 2 , wherein the processor is configured to adjust the prior probability map by increasing, in the prior probability map, a probability of the user-specified brain tissue class in the area of misclassification.

4. The system according to claim 3 , wherein the processor is configured to increase, in the prior probability map, the probability of the user-specified brain tissue class in the area of misclassification to substantially 100%.

5. The system according to claim 1 , wherein the user interface subsystem is configured to enable the user to indicate the correction of the misclassification by changing a probability ratio between grey matter tissue and white matter tissue.

6. The system according to claim 5 , wherein the user interface subsystem is configured to enable the user to incrementally change the probability ratio.

7. The system according to claim 1 , wherein the user interaction subsystem configured to enable the user to indicate the area of misclassification in the tissue classification map as displayed on the display.

8. The system according to claim 1 , wherein the user interface subsystem is configured to:
display the image on the display, and
enable the user to indicate the area of misclassification in the tissue classification map by indicating a region of interest in the image.

9. The system according to claim 1 , wherein the automated tissue classification technique is based on Expectation Maximization.

10. Workstation comprising the system according to claim 1 .

11. Imaging apparatus comprising the system according to claim 1 .

12. Method for brain tissue classification, comprising:
accessing an image of a brain of a patient;
applying an automated tissue classification technique to the image based on a prior probability map, the prior probability map being registered to the image and being indicative of a probability of a particular location in the brain belonging to a particular brain tissue class, the automated tissue classification technique providing as output a tissue classification map of the brain of the patient;
enabling a user to indicate a point in the area of misclassification, thereby obtaining a user-indicated point;
displaying the tissue classification map on a display;
receiving input commands from a user device operable by the user, wherein the input commands represent user feedback which is indicative of i) an area of misclassification in the tissue classification map and ii) a correction of the misclassification; the user feedback indicating a point in the area of misclassification, thereby obtaining a user-indicated point;
determining a boundary of the area of misclassification based on the user-indicated point;
adjusting the prior probability map based on the user feedback, thereby obtaining an adjusted prior probability map; and
re-applying the automated tissue classification technique to the image based on the adjusted prior probability map.

13. A non-transitory computer readable medium comprising instructions for causing a processor to perform a method comprising the steps of:
accessing an image of a brain of a patient;
applying an automated tissue classification technique to the image based on a prior probability map, the prior probability map being registered to the image and being indicative of a probability of a particular location in the brain belonging to a particular brain tissue class, the automated tissue classification technique providing as output a tissue classification map of the brain of the patient;
displaying the tissue classification map on a display;
receiving input commands from a user device operable by the user, wherein the input commands represent user feedback which is indicative of i) an area of misclassification in the tissue classification map and ii) a correction of the misclassification; the user feedback indicating a point in the area of misclassification, thereby obtaining a user-indicated point;
determining a boundary of the area of misclassification based on the user-indicated point;
adjusting the prior probability map based on the user feedback, thereby obtaining an adjusted prior probability map; and
re-applying the automated tissue classification technique to the image based on the adjusted prior probability map.

Assignees

• Koninklijke Philips Nv

Inventors

• Wenzel Fabian
• Stehle Thomas Heiko
• Zagorchev Lyubomir Georgiev
• Peters Jochen
• Bergtholdt Martin
• Meyer Carsten

Classifications

• G06F18/2415

  based on parametric or probabilistic models, e.g. based on likelihood ratio or false acceptance rate versus a false rejection rate · CPC title

• G06T7/0012 Primary

  Biomedical image inspection · CPC title

• G06T2207/20128

  Atlas-based segmentation · CPC title

• G06T2200/24

  involving graphical user interfaces [GUIs] · CPC title

• A61B2576/026

  for the brain · CPC title