Protease inhibitors
US-9200006-B2 · Dec 1, 2015 · US
Protease inhibitors
US10329266B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10329266-B2 |
| Application number | US-201815941947-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 30, 2018 |
| Priority date | Sep 24, 2008 |
| Publication date | Jun 25, 2019 |
| Grant date | Jun 25, 2019 |
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- Title
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- Abstract
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- Assignees and inventors
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Abstract
Official abstract text for this publication.
Compounds of the formula II: wherein R 1 and R 2 are independently H, F or CH 3 ; or R 1 forms an ethynyl bond and R 2 is H or C 3 -C 6 cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF 3 , OMe or halo; R 3 is C 1 -C 3 alkyl or C 3 -C 6 cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or methoxy, when R 3 is C 3 -C 6 cycloalkyl it may alternatively be gem substituted with fluoro; R 4 is methyl or fluoro; m is 0, 1 or 2; E is a bond, or thiazolyl, optionally substituted with methyl or fluoro; A 1 is CH or N, A 2 is CR 6 R7 or NR 6 , provided at least one of A 1 and A 2 comprises N; R 6 is H, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 3 alkyl-O—C 1 -C 3 alkyl, or when A 2 is C, R 6 can also be C 1 -C 4 alkoxy or F; R 7 is H, C 1 -C 4 alkyl or F or a pharmaceutically acceptable salt, N-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound of the formula 2. A process of preparation of the compound according to claim 1 , comprising the step of deprotecting the ketal compound of the formula with trifluoroacetic acid to obtain the ketone of claim 1 .
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for disorders of the blood or the extracellular fluid · CPC title
Antineoplastic agents · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Centrally acting analgesics, e.g. opioids · CPC title
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- What does patent US10329266B2 cover?
- Compounds of the formula II: wherein R 1 and R 2 are independently H, F or CH 3 ; or R 1 forms an ethynyl bond and R 2 is H or C 3 -C 6 cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF 3 , OMe or halo; R 3 is C 1 -C 3 alkyl or C 3 -C 6 cycloalkyl, either of which is optionally substitut…
- Who is the assignee on this patent?
- Medivir Ab
- What technology area does this patent fall under?
- Primary CPC classification C07D491/048. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).