Cell injection needle

Patent metadata

Field	Value
Publication number	US-10328213-B2
Application number	US-201414211702-A
Country	US
Kind code	B2
Filing date	Mar 14, 2014
Priority date	Mar 15, 2013
Publication date	Jun 25, 2019
Grant date	Jun 25, 2019

Abstract

Methods and apparatus are provided for treating tissue with apparatus that includes an priming portion for initiating a healing response in the tissue to be treated, and which delivers a bioactive agent during or after preparing tissue adjacent the apparatus, as by generating or aiding a healing, regeneration or repair response in the tissue. The priming portion may comprise an abrasive surface, fluid ejection ports, and/or stimulation by electrical, thermal, or light energy.

First claim

What is claimed is:

1. A cell delivery system, comprising: an elongated needle body comprising a sheath having a longitudinal axis, an inner diameter defining a cavity adapted to hold a plurality of cells and a distal end surface, and a central portion partially within the sheath and along the longitudinal axis, the central portion including an end region, the sheath and central portion being movable with respect to each other along or around the longitudinal axis, the sheath terminating in a distal tip adapted for tissue penetration, said sheath and central portion capable of transition from a first configuration for insertion into tissue, in which the end region is positioned within the distal end surface of the sheath to seal the cavity to provide a continuous smooth transition between an external surface of the central portion and an exterior surface of the sheath such that the external surface of the central portion has a flush contact area with the distal surface of the sheath, to a second configuration in which the end region is configured to extend distally from the sheath to open the cavity for delivery of cells when a portion of said body is adjacent a tissue location where therapy is desired, and wherein from the second configuration the central portion is configured to move into the sheath until the end region is positioned within the distal end surface of the sheath, wherein the sheath and central portion are capable of relative rotational movement around the longitudinal axis during transition from the first configuration to the second configuration.

2. The system of claim 1 , further comprising:
a first lumen in fluid communication with said cavity.

3. The system of claim 1 , wherein:
one or both of the sheath and the central portion move along said longitudinal axis in transitioning from said first configuration to said second configuration.

4. The system of claim 1 , further comprising:
a plurality of cells positioned inside said cavity.

5. The system of claim 1 , wherein the sheath and central portion are capable of relative translational movement along the longitudinal axis to transition from the first configuration to the second configuration.

6. The system of claim 1 , wherein the sheath and central portion are capable of relative rotational movement around the longitudinal axis to transition from the first configuration to the second configuration.

7. The system of claim 1 , wherein in the second configuration delivery of cells can occur through a separation between the end region and the sheath.

8. The system of claim 1 , wherein the central portion includes a priming portion, and wherein the central portion is movable with respect to the sheath and with respect to tissue adjacent the priming portion at the same time.

9. The system of claim 1 , further comprising:
a priming portion adjacent to said tissue penetrating distal tip;
wherein said priming portion is arranged to generate a healing or regeneration response in tissue adjacent to said priming portion prior to the arrival of cells from said cavity to said tissue.

10. The system of claim 9 , wherein:
said priming portion comprises at least one fluid ejection port.

11. The system of claim 1 , wherein the central portion includes a carrier shaft inside the sheath.

12. The system of claim 11 , further comprising a priming portion at a distal portion of the carrier shaft.

13. A cell delivery system, comprising: an elongated body comprising an outer sheath portion defining a cell-carrying portion to hold a plurality of cells, the outer sheath portion terminating at a tissue-penetrating tip arranged to penetrate tissue as the tissue-penetrating tip is forced into bodily tissue, the body further including a central portion extending through the outer sheath portion, the central portion having a distal end region adapted to move along or around a longitudinal axis of said outer sheath portion, the body further having a priming portion positionable adjacent to said tissue-penetrating tip during a first configuration; said outer sheath portion and central portion capable of transition from the first configuration for insertion into tissue, in which the distal end region is fully positioned within the tissue-penetrating distal tip of the outer sheath to seal the cell-carrying portion such that the distal end region of the central portion has a flush contact area with the tissue-penetrating tip of the outer sheath portion in the insertion configuration to a second configuration in which the distal end region is configured to extend distally from the outer sheath to open the cell-carrying portion for delivery of cells; wherein sail outer sheath portion and said central portion are capable of relative rotational movement around the longitudinal axis during transition from the first configuration to the second configuration.

14. The system of claim 13 , further comprising:
a plurality of cells positioned inside said cell-carrying portion.

15. The system of claim 13 , wherein:
said priming portion comprises at least one fluid ejection port.

Assignees

• Muffin Inc

Inventors

• Sisken Richard B
• Pruchnic Ryan
• Fischer Jr Frank J
• Charlebois Steven

Classifications

• A61B18/24

  with a catheter (A61B18/26, A61B18/28 take precedence) · CPC title

• A61M5/1582

  Double lumen needles · CPC title

• A61M25/0069

  Tip not integral with tube · CPC title

• A61M25/007

  Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked · CPC title

• A61M5/34 Primary

  Constructions for connecting the needle {, e.g. to syringe nozzle or needle hub (connecting catheter tubes to hubs A61M25/0014)} · CPC title