Compound useful for the treatment of degenerative and inflammatory diseases
US-9707237-B2 · Jul 18, 2017 · US
US10328081B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10328081-B2 |
| Application number | US-201715651116-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 17, 2017 |
| Priority date | Jun 26, 2009 |
| Publication date | Jun 25, 2019 |
| Grant date | Jun 25, 2019 |
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Official abstract text for this publication.
A novel compound able to inhibit JAK is disclosed, that comprises a compound according to Formula I: or a pharmaceutically acceptable salt thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
Opening claim text (preview).
What is claimed is: 1. A method for the treatment of psoriatic arthritis, comprising: administering to a subject in need thereof an amount of a compound according to Formula I: or a pharmaceutically acceptable salt thereof sufficient to effect said treatment. 2. The method according to claim 1 , wherein the compound is administered in combination with one or more further therapeutic agents selected from agents for the treatment of psoriatic arthritis. 3. The method according to claim 2 , wherein the compound is administered in combination with one further therapeutic agent selected from agents for the treatment of psoriatic arthritis. 4. A method for the treatment of psoriatic arthritis, comprising: administering to a subject in need thereof an amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound according to Formula I: or a pharmaceutically acceptable salt thereof, sufficient to effect said treatment. 5. A method for the treatment of psoriatic arthritis, comprising: administering to a subject in need thereof an amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier, a pharmaceutically effective amount of a compound according to Formula I: or a pharmaceutically acceptable salt thereof, and a further therapeutic agent, sufficient to effect said treatment. 6. The method according to claim 4 , wherein the pharmaceutical composition is administered in combination with one or more further therapeutic agents selected from agents for the treatment of psoriatic arthritis. 7. The method according to claim 6 , wherein the pharmaceutical composition is administered in combination with one further therapeutic agent selected from agents for the treatment of psoriatic arthritis. 8. The method according to claim 5 , wherein the further therapeutic agent is an agent for the treatment of psoriatic arthritis.
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