Ophthalmic injection assembly and injection device, and use method
US-2024315871-A1 · Sep 26, 2024 · US
Intraocular delivery of bioactive molecules using iontophoresis
US10327946B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10327946-B2 |
| Application number | US-201514977048-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 21, 2015 |
| Priority date | Dec 19, 2014 |
| Publication date | Jun 25, 2019 |
| Grant date | Jun 25, 2019 |
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- Title
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- Abstract
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Abstract
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Iontophoresis, a minimally-invasive methodology that uses a weak electric current to enhance penetration of ionized molecules into tissues, was found to be an effective technique for the intraocular delivery of large bioactive molecules, specifically lutein.
First claim
Opening claim text (preview).
We claim: 1. A method of depositing at least one carotenoid in ocular tissues, comprising the steps of formulating a liposome having a positive zeta potential containing the at least one carotenoid in an amount effective to increase macular pigment in the ocular tissues of a subject, charging an iontophoresis device with a composition of the liposome containing at least one carotenoid, applying the iontophoresis device to the eye of the subject, and operating the iontophoresis device, wherein the at least one carotenoid is selected from the group consisting of lutein and zeaxanthin. 2. A method of treating or ameliorating age-related macular degeneration, comprising the steps of formulating a liposome having a positive zeta potential containing at least one carotenoid in an amount effective to increase macular pigment in the ocular tissues of a subject, charging an iontophoresis device with a composition of the liposome, applying the iontophoresis device to the eye of a subject, and operating the iontophoresis device, wherein the at least one carotenoid is selected from the group consisting of lutein and zeaxanthin. 3. The method of claim 2 , wherein treating or ameliorating age-related macular degeneration is preventing or delaying the progression of age-related macular degeneration.
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Inventors
Classifications
Ophthalmic agents · CPC title
Apparatus for iontophoresis, {i.e. transfer of media in ionic state by an electromotoric force into the body}, or cataphoresis · CPC title
Devices for introducing or retaining media, e.g. remedies, in cavities of the body (A61M25/00 takes precedence {; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008}) · CPC title
- A61F9/0008Primary
Introducing ophthalmic products into the ocular cavity or retaining products therein (putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00) · CPC title
Drugs for disorders of the senses · CPC title
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Frequently asked questions
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- What does patent US10327946B2 cover?
- Iontophoresis, a minimally-invasive methodology that uses a weak electric current to enhance penetration of ionized molecules into tissues, was found to be an effective technique for the intraocular delivery of large bioactive molecules, specifically lutein.
- Who is the assignee on this patent?
- Kemin Ind Inc
- What technology area does this patent fall under?
- Primary CPC classification A61F9/0008. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 25 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).