Macrocyclic peptidomimetic protease inhibitor and use thereof
US-2024327458-A1 · Oct 3, 2024 · US
Pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the peptide having the ability to inhibit angiotensin-1 converting enzyme as an active ingredient
US10323062B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10323062-B2 |
| Application number | US-201514627642-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 20, 2015 |
| Priority date | Aug 24, 2012 |
| Publication date | Jun 18, 2019 |
| Grant date | Jun 18, 2019 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention relates to a peptide separated from the fraction of oyster enzyme hydrate displaying the ability of suppressing angiotensin converting enzyme (ACE) and a pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the said peptide as an active ingredient. Particularly, the peptide separated from the fraction of the oyster enzyme hydrate of the present invention significantly inhibits ACE activity, and thus brings blood pressure regulating effect and antihypertensive effect. Therefore, the fraction of the oyster enzyme hydrate of the invention or the peptide separated from the same can be effectively used as an active ingredient of a pharmaceutical composition for the prevention or treatment of cardiovascular disease.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for treating cardiovascular disease comprising the step of administering at least one peptide selected from the group consisting of SEQ ID NOs: 6 and SEQ. ID NOs: 8-11 to a subject having cardiovascular disease. 2. The method according to claim 1 , wherein the peptide is separated from an oyster enzyme hydrate. 3. The method according to claim 2 , wherein the enzyme is protease. 4. The method according to claim 1 , wherein the peptide selected from the group consisting of SEQ ID NOs: 6 and SEQ ID NOs: 8-11 inhibits angiotensin conversing enzyme (ACE). 5. The method according to claim 1 , wherein the cardiovascular disease is one or more diseases selected from the group consisting of hypertension, heart disease, stroke, thrombosis, angina pectoris, heart failure, myocardial infarction, atherosclerosis, and arteriosclerosis.
Assignees
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Classifications
and aromatic or cycloaliphatic · CPC title
and aromatic or cycloaliphatic · CPC title
the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr · CPC title
Drugs for disorders of the cardiovascular system · CPC title
the side chain containing 2 to 4 carbon atoms · CPC title
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- What does patent US10323062B2 cover?
- The present invention relates to a peptide separated from the fraction of oyster enzyme hydrate displaying the ability of suppressing angiotensin converting enzyme (ACE) and a pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the said peptide as an active ingredient. Particularly, the peptide separated from the fraction of the oyster enzyme hydrate…
- Who is the assignee on this patent?
- Univ Industry Cooperation Group Kyung Hee Univ, Nat Univ Gyeongsang Iacf
- What technology area does this patent fall under?
- Primary CPC classification C07K5/06086. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 18 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).