Radiosynthesiser add-on device

Patent metadata

Field	Value
Publication number	US-10315179-B2
Application number	US-201615546988-A
Country	US
Kind code	B2
Filing date	Mar 16, 2016
Priority date	Mar 16, 2015
Publication date	Jun 11, 2019
Grant date	Jun 11, 2019

Abstract

The present invention relates to an automated radiosynthesis device adapted for the addition of multiple additional components. The automated radiosynthesis device of the invention enables a wider range of radiochemical synthetic processes to be carried out in an automated fashion.

First claim

The invention claimed is:

1. An automated radiosynthesis device comprising:
(i) a plurality of connectors for removably attaching a disposable kit;
(ii) a plurality of actuators to selectively control moving parts of said disposable kit;
(iii) a control unit for directing the selective control of the moving parts of said disposable kit by said plurality of actuators;
(iv) a reaction vessel heating well;
(v) an inert gas conduit;
(vi) a vacuum conduit;
(vii) a radioisotope conduit;
(viii) means to fix add-on devices onto the radiosynthesis device at various locations, wherein said means to fix add-on devices comprises a rail and means for securing said add-on devices to said rail.

2. The device of claim 1 , wherein said connectors are selected from fasteners and/or fluidic connectors.

3. The device as device of claim 2 , wherein said fluidic connectors are selected from push-on type connectors, luer slip connectors and/or luer screw connectors.

4. The device of claim 1 , wherein said disposable kit is suitable for the synthesis of a radiotracer compound.

5. The device of claim 4 , wherein said radiotracer compound is a positron-emission tomography (PET) tracer.

6. The device of claim 5 , wherein said radiotracer compound is an 18 F-labelled PET tracer.

7. The device of claim 1 , wherein said disposable kit is a single-use cassette.

8. The device of claim 1 , wherein said plurality of actuators is selected from rotatable arms for stopcocks of valves, linear actuators, arms that press onto reagent vials and/or pinch valves.

9. The device of claim 1 , wherein said moving parts of said disposable kit are selected from the reagent vials, syringes and/or valves.

10. The device of claim 1 , wherein said control unit includes software comprising instructions for a particular radiosynthesis method to be carried out on said disposable kit attached to said automated radiosynthesis device.

11. The device of claim 1 , wherein said reaction vessel heating well is fixed to said means to fix add-on devices.

12. The device of claim 1 , wherein said means to fix add-on devices is part of a cassette drawer of the radiosynthesis device.

13. The device of claim 1 , wherein said rail is a T-shaped rail.

14. The device of claim 1 , wherein said means for securing said devices to said rail comprises a T-shaped nut and associated screw.

15. The device of claim 1 , wherein said add-on devices are selected from:
an additional reaction vessel heating well;
a radioactivity detector;
a temperature sensor;
a vial holder for additional reagents;
a solid-phase extraction (SPE) cartridge heating or cooling device;
additional actuators to extend the disposable kit operation capability; and/or, a web cam.

16. An automated radiosynthesis device comprising:
(i) a plurality of connectors for removably attaching a disposable kit;
(ii) a plurality of actuators to selectively control moving parts of said disposable kit;
(iii) a control unit for directing the selective control of the moving parts of said disposable kit by said plurality of actuators;
(iv) a reaction vessel heating well;
(v) an inert gas conduit;
(vi) a vacuum conduit;
(vii) a radioisotope conduit;
(viii) means to fix add-on devices onto the radiosynthesis device at various locations,
wherein said means to fix add-on devices is part of a cassette drawer of the radiosynthesis device comprises a T-shaped rail and means for securing said add-on devices to said T-shaped rail,
wherein said means for securing said devices to said rail comprises a T-shaped nut and associated screw, and
wherein said reaction vessel heating well is fixed to said means to fix add-on devices.

17. The device of claim 16 , wherein said plurality of connectors is selected from fasteners and/or fluidic connectors, said fluidic connectors are selected from the group comprising push-on type connectors, luer slip connectors or luer screw connectors, and/or said disposable kit is a single-use cassette suitable for the synthesis of a radiotracer compound.

18. The device of claim 17 , wherein said radiotracer compound is a 18 F-labelled positron-emission tomography (PET) tracer.

19. The device of claim 16 , wherein said plurality of actuators is selected from rotatable arms for stopcocks of valves, linear actuators, arms that press onto reagent vials and/or pinch valves, said moving parts of said disposable kit are selected from reagent vials, syringes and valves, and/or said control unit includes software comprising instructions for a particular radiosynthesis method to be carried out on said disposable kit attached to said automated radiosynthesis device.

20. The device of claim 16 , wherein said add-on devices are selected from:
an additional reaction vessel heating well;
a radioactivity detector;
a temperature sensor;
a vial holder for additional reagents;
a solid-phase extraction (SPE) cartridge heating or cooling device;
additional actuators to extend the disposable kit operation capability; and/or, a web cam.

Assignees

• Ge Healthcare Ltd

Inventors

• Dumont Philippe

Classifications

• B01J2219/00799

  Cup-shaped · CPC title

• C07B59/00

  Introduction of isotopes of elements into organic compounds {; Labelled organic compounds per se} · CPC title

• B01J2219/00918

  by adsorption · CPC title

• B01J19/004 Primary

  Multifunctional apparatus for automatic manufacturing of various chemical products (sequential reactions B01J19/0046) · CPC title

• B01J2219/00986

  Microprocessor · CPC title