Modular surface functionalization of polyisobutylene-based materials

Patent metadata

Field	Value
Publication number	US-10314945-B2
Application number	US-201715490080-A
Country	US
Kind code	B2
Filing date	Apr 18, 2017
Priority date	Feb 9, 2015
Publication date	Jun 11, 2019
Grant date	Jun 11, 2019

Abstract

A polymer composite includes a functionalized polyisobutylene and an additional polyisobutylene-containing material. The functionalized polyisobutylene includes an α-lipoic acid functional group. A method for producing the polymer composite includes providing the additional polyisobutylene-containing material as a substrate having a surface, and coating the surface of the substrate with the functionalized polyisobutylene. A method for producing a coated substrate including the polymer composite includes providing a polymer combination including the functionalized polyisobutylene and the additional polyisobutylene-containing material, and depositing the polymer combination on to a substrate to thereby form the coated substrate.

First claim

What is claimed is:

1. A polymer composite comprising a functionalized polyisobutylene and an additional polyisobutylene-containing material, wherein the functionalized polyisobutylene includes an α-lipoic acid functional group.

2. The composite of claim 1 , wherein the functionalized polyisobutylene and the additional polyisobutylene-containing material are not attached by a covalent bond.

3. The composite of claim 1 , wherein the additional polyisobutylene-containing material is non-functionalized.

4. The composite of claim 1 , wherein the additional polyisobutylene-containing material is selected from the group consisting of linear polyisobutylene thermoplastic elastomers (TPEs), star polyisobutylene TPEs, and arborescent polyisobutylene TPEs.

5. The composite of claim 1 , wherein the additional polyisobutylene-containing material is an arborescent polyisobutylene-based TPE with poly(para-methyl styrene) end blocks (arbPIB-MS).

6. A coated substrate comprising the composite of claim 1 , coated on a substrate.

7. The coated substrate of claim 6 , wherein the substrate is a breast implant.

8. The coated substrate of claim 6 , wherein the composite has a protein adsorption less than 25 ng/cm 2 with respect to the protein fibrinogen.

9. The coated substrate of claim 6 , wherein the functionalized polyisobutylene forms a functionalized polyisobutylene compound layer having a thickness, wherein the thickness of the functionalized polyisobutylene compound layer is less than 1 micron.

10. The coated substrate of claim 6 , wherein the functionalized polyisobutylene forms a functionalized polyisobutylene compound layer having a thickness, wherein the thickness of the functionalized polyisobutylene compound layer is less than 20 nm.

11. The coated substrate of claim 6 , the composite having a thickness, wherein the thickness of the composite is less than 1 micron.

12. The coated substrate of claim 6 , the composite having a thickness, wherein the thickness of the composite is less than 20 nm.

13. The coated substrate of claim 6 , the composite having a surface, wherein a drug or molecule is attached to the surface of the composite.

14. A method for producing the polymer composite of claim 1 , comprising steps of providing the additional polyisobutylene-containing material as a substrate having a surface, and coating the surface of the substrate with the functionalized polyisobutylene.

15. The method of claim 14 , wherein the step of coating includes spray coating the functionalized polyisobutylene onto the surface of the substrate.

16. The method of claim 14 , wherein the step of coating includes dipping the surface of the substrate in a solution containing the functionalized polyisobutylene.

17. A method for producing a coated substrate including the polymer composite of claim 1 , comprising steps of
providing a polymer combination comprising the functionalized polyisobutylene and the additional polyisobutylene-containing material, and
depositing the polymer combination on to a substrate to thereby form the coated substrate.

18. The method of claim 17 , wherein the step of depositing is electrospraying.

19. The method of claim 17 , wherein the step of depositing is electrospinning.

Assignees

• Puskas Judit E
• Albarran Alejandra Alvarez
• Rosenthal Kim Emily Q
• Univ Akron

Inventors

• Puskas Judit E
• Albarran Alejandra Alvarez
• Rosenthal-Kim Emily Q

Classifications

• C08J7/0427

  with only one layer of a composition containing a polymer binder (with more layers C08J7/042) · CPC title

• C08F8/30

  Introducing nitrogen atoms or nitrogen-containing groups · CPC title

• A61L27/34

  Macromolecular materials · CPC title

• C08J2423/26

  modified by chemical after-treatment · CPC title

• C08G81/02

  at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds · CPC title