Nutritional composition

Patent metadata

Field	Value
Publication number	US-10300085-B2
Application number	US-201515128682-A
Country	US
Kind code	B2
Filing date	Mar 20, 2015
Priority date	Mar 24, 2014
Publication date	May 28, 2019
Grant date	May 28, 2019

Abstract

A nutrient composition, a lipid metabolism-improving agent, and prophylactic and/or therapeutic agents typically for inflammatory bowel diseases, immune disorders, cancers, non-alcoholic steatohepatitis, obesity, diabetes, and hypercholesterolemia each contain a cellulose acetate having a total degree of acetyl substitution of 0.4 to 1.1. The cellulose acetate may be one having a compositional distribution index (CDI) of 2.0 or less, where the CDI is defined by the formula:

CDI=(Measured value of half height width of chemical composition)/(Theoretical value of half height width of chemical composition)
where the measured value of half height width of chemical composition represents a half height width of chemical composition determined by HPLC analysis of a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate (sample), and

the theoretical value of half height width of chemical composition =2.35482√{square root over (3* DPw *( DS /3)*(1− DS /3))}/ DPw   [Math. 1]

where DS is the total degree of acetyl substitution; and DPw is a weight-average degree of polymerization determined by a GPC-light scattering method using a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate (sample).

First claim

The invention claimed is:

1. A method for treatment of cancer in a subject in need thereof, comprising
administering to the subject an effective amount of a water-soluble dietary fiber selected from a cellulose acetate having a total degree of acetyl substitution of 0.4 to 1.1,
wherein the cellulose acetate comprises a cellulose acetate material having a compositional distribution index (CDI) of 2.0 or less, the compositional distribution index being specified by a formula:
CDI=(Measured value of half height width of chemical composition)/(Theoretical value of half height width of chemical composition) wherein:
the measured value of half height width of chemical composition is a half height width of chemical composition determined by high-performance liquid chromatographic (HPLC) analysis of a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate material; and
the theoretical value of half height width of chemical composition is specified by a formula:
Theoretical value of half height width of chemical composition =2.35482√{square root over (3* DPw* ( DS /3)*(1− DS/ 3))}/ DPw   [Math. 1]

wherein:
DS is the total degree of acetyl substitution;
DPw is a weight-average degree of polymerization determined by a gel permeation chromatography-light scattering method using a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate material.

2. The method according to claim 1 ,
wherein the subject is a livestock.

3. The method according to claim 1 ,
wherein the cancer is selected from the group consisting of liver cancer, colon cancer, mammary cancer, lung cancer, ovarian cancer, prostatic cancer, gastric cancer, and pancreatic cancer.

4. A method for treatment of non-alcoholic steatohepatitis in a subject in need thereof, comprising
administering to the subject an effective amount of a water-soluble dietary fiber selected from a cellulose acetate having a total degree of acetyl substitution of 0.4 to 1.1,
wherein the cellulose acetate comprises a cellulose acetate material having a compositional distribution index (CDI) of 2.0 or less, the compositional distribution index being specified by a formula:
CDI=(Measured value of half height width of chemical composition)/(Theoretical value of half height width of chemical composition)

wherein:
the measured value of half height width of chemical composition is a half height width of chemical composition determined by high-performance liquid chromatographic (HPLC) analysis of a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate material; and
the theoretical value of half height width of chemical composition is specified by a formula:
Theoretical value of half height width of chemical composition =2.35482√{square root over (3* DPw* ( DS /3)*(1− DS/ 3))}/ DPw   [Math. 1]

wherein:
DS is the total degree of acetyl substitution;
DPw is a weight-average degree of polymerization determined by a gel permeation chromatography-light scattering method using a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate material.

5. The method according to claim 4 ,
wherein the subject is a livestock.

6. A method for treatment of obesity and/or diabetes in a subject in need thereof, comprising
administering to the subject an effective amount of a water-soluble dietary fiber selected from a cellulose acetate having a total degree of acetyl substitution of 0.4 to 1.1,
wherein the cellulose acetate comprises a cellulose acetate material having a compositional distribution index (CDI) of 2.0 or less, the compositional distribution index being specified by a formula:
CDI =(Measured value of half height width of chemical composition)/(Theoretical value of half height width of chemical composition)

wherein:
the measured value of half height width of chemical composition is a half height width of chemical composition determined by high-performance liquid chromatographic (HPLC) analysis of a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate material; and
the theoretical value of half height width of chemical composition is specified by a formula:
Theoretical value of half height width of chemical composition =2.35482√{square root over (3* DPw* ( DS /3)*(1− DS/ 3))}/ DPw   [Math. 1]

wherein:
DS is the total degree of acetyl substitution;
DPw is a weight-average degree of polymerization determined by a gel permeation chromatography-light scattering method using a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate material.

7. The method according to claim 6 ,
wherein the subject is a livestock.

8. A method for treatment of hypercholesterolemia in a subject in need thereof, comprising
administering to the subject an effective amount of a water-soluble dietary fiber selected from a cellulose acetate having a total degree of acetyl substitution of 0.4 to 1.1,
wherein the cellulose acetate comprises a cellulose acetate material having a compositional distribution index (CDI) of 2.0 or less, the compositional distribution index being specified by a formula:
CDI =(Measured value of half height width of chemical composition)/(Theoretical value of half height width of chemical composition)

wherein:
the measured value of half height width of chemical composition is a half height width of chemical composition determined by high-performance liquid chromatographic (HPLC) analysis of a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate material; and
the theoretical value of half height width of chemical composition is specified by a formula:
Theoretical value of half height width of chemical composition=2.35482√{square root over (3* DPw* ( DS /3)*(1− DS/ 3))}/ DPw   [Math. 1]

wherein:
DS is the total degree of acetyl substitution;
DPw is a weight-average degree of polymerization determined by a gel permeation chromatography-light scattering method using a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate material.

9. The method according to claim 8 ,
wherein the subject is a livestock.

Assignees

• Daicel Corp

Inventors

• Shimamoto Shu
• Nakamura Toshikazu
• Ukita Shizuka
• Nakamura Tsuyoshi
• Yamauchi Ryoko
• Kobayashi Hiroshi
• Morita Tatsuya
• Genda Tomomi

Classifications

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P37/02

  Immunomodulators · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title