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Compositions and methods for use in diagnosis of alzheimer's disease
US10295550B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10295550-B2 |
| Application number | US-201515527464-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 17, 2015 |
| Priority date | Nov 17, 2014 |
| Publication date | May 21, 2019 |
| Grant date | May 21, 2019 |
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- Title
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Abstract
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Provided are compositions and methods useful in the diagnosis of Alzheimer's Disease (AD). The methods involve immunologically testing biological samples for an amount of high molecular weight kininogen (HK) and cleaved high molecular weight kininogen (HKc), wherein determining less HK relative to a normal control, or determining more HKc relative to a normal control, or a combination thereof, aids in diagnosis of AD. Hybridomas and monoclonal antibodies bind with specificity to either HK alone, or to both HK and HKc. Kits for use in immunological AD testing using the mAbs are also provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for aiding in the diagnosis of Alzheimer's Disease (AD) comprising testing a plasma sample obtained from a human subject suspected of having or at risk for developing AD, wherein the testing comprises using an enzyme-linked immunosorbent assay (ELISA) for high molecular weight kininogen (HK) and cleaved high molecular weight kininogen (HKc) using a capture antibody in the ELISA that is a hamster antibody that binds with specificity to a peptide consisting of the sequence IQSDDDWIPDIQIDPNGLSC (SEQ ID NO:6) and determining less HK relative to a normal control, or determining more HKc relative to a normal control, or a combination thereof, to aid in diagnosis of AD. 2. The method of claim 1 , wherein the capture antibody is covalently attached to a substrate. 3. The method of claim 1 , wherein the ELISA assay further comprises using a detectably labeled detection antibody that binds with specificity to HK and does not bind with specificity to HKc.
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Classifications
Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity · CPC title
Kallidins; Bradykinins; Related peptides · CPC title
against material from animals or humans · CPC title
having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title
Alzheimer · CPC title
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- What does patent US10295550B2 cover?
- Provided are compositions and methods useful in the diagnosis of Alzheimer's Disease (AD). The methods involve immunologically testing biological samples for an amount of high molecular weight kininogen (HK) and cleaved high molecular weight kininogen (HKc), wherein determining less HK relative to a normal control, or determining more HKc relative to a normal control, or a combination thereof, …
- Who is the assignee on this patent?
- Univ Rockefeller
- What technology area does this patent fall under?
- Primary CPC classification G01N33/6896. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue May 21 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).