DNA/Dithiocarbamato phosphine metal complex

Patent metadata

Field	Value
Publication number	US-10294254-B2
Application number	US-201816112188-A
Country	US
Kind code	B2
Filing date	Aug 24, 2018
Priority date	Apr 22, 2016
Publication date	May 21, 2019
Grant date	May 21, 2019

Abstract

Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.

First claim

The invention claimed is:

1. A DNA/dithiocarbamato(phosphine)metal complex, comprising:
a dithiocarbamato(phosphine)gold(I) compound represented by formula (I):

a salt thereof, a solvate thereof, or a combination thereof; and
DNA complexed to the dithiocarbamato(phosphine)gold(I) compound;
wherein R 1 and R 2 are alkyl groups independently selected from the group consisting of methyl, ethyl, and isopropyl;
R 3 , R 4 , and R 5 are independently selected from the group consisting of an optionally substituted C 1 -C 3 alkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted vinyl, an optionally substituted alkoxy, and an optionally substituted aryloxy; and
with the proviso that R 1 , R 2 , R 3 , R 4 , and R 5 are not each an ethyl.

2. The DNA/dithiocarbamato(phosphine)metal complex of claim 1 , wherein R 1 and R 2 are the same unsubstituted alkyl group, and R 3 , R 4 , and R 5 are the same optionally substituted C 1 -C 3 alkyl group.

3. The DNA/dithiocarbamato(phosphine)metal complex of claim 2 , wherein R 1 and R 2 are ethyls, and R 3 , R 4 , and R 5 are methyls.

4. The DNA/dithiocarbamato(phosphine)metal complex of claim 1 , wherein R 3 , R 4 , and R 5 are a C 1 -C 2 alkyl group.

5. The DNA/dithiocarbamato(phosphine)metal complex of claim 1 , wherein R 1 and R 2 are methyls and R 3 , R 4 , and R 5 are ethyls.

Assignees

• Univ King Fahd Pet & Minerals
• Univ King Saud

Inventors

• Al-Jaroudi Said S
• Alhoshani Ali
• Altaf Muhammad
• Isab Anvarhusein Abdulkadir

Classifications

• G01N33/57515

  of the breast · CPC title

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• A61K9/0053

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• G01N2800/52

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• A61N1/30

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