Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
US-9221812-B2 · Dec 29, 2015 · US
Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins
US10294205B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10294205-B2 |
| Application number | US-201515303670-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 27, 2015 |
| Priority date | Apr 16, 2014 |
| Publication date | May 21, 2019 |
| Grant date | May 21, 2019 |
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- Title
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Abstract
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There is provided a compound of formula I, having the structure: wherein R 1 to R 5 have the meanings given in the description.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound selected from the group consisting of: or a pharmaceutically acceptable salt or solvate, or a pharmaceutically functional derivative thereof. 2. The compound according to claim 1 , wherein the compound is isotopically labelled. 3. A method of determining the presence or location of a free thiol group in a tissue sample, the method comprising contacting the tissue sample with a compound according to claim 1 , as an irreversible binder to the free thiol group. 4. The method of claim 3 , wherein the free thiol group is part of a peptide or a protein. 5. A compound according to claim 1 , for use in medicine. 6. The method of claim 3 , wherein the compound according to claim 1 performs as an imaging or diagnostic agent. 7. The method of claim 6 , wherein the compound is isotopically labelled.
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substituted in position 7 · CPC title
having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton · CPC title
with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton · CPC title
The ring being saturated · CPC title
- C07D209/14Primary
Radicals substituted by nitrogen atoms, not forming part of a nitro radical · CPC title
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Frequently asked questions
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- What does patent US10294205B2 cover?
- There is provided a compound of formula I, having the structure: wherein R 1 to R 5 have the meanings given in the description.
- Who is the assignee on this patent?
- Univ Nanyang Tech
- What technology area does this patent fall under?
- Primary CPC classification C07D209/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 21 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).