Drug for treating artery-related diseases, and use thereof
US-2022395476-A1 · Dec 15, 2022 · US
Pharmaceutical or food composition comprising Oldenlandia brachypoda, Spergularia marina, Disporum smilacinum, Persicaria posumbu, or Geum aleppicum
US10293009B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10293009-B2 |
| Application number | US-201314655703-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 12, 2013 |
| Priority date | Dec 26, 2012 |
| Publication date | May 21, 2019 |
| Grant date | May 21, 2019 |
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- Title
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Abstract
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The present disclosure relates to a pharmaceutical composition or a food composition which has excellent activity of stimulating enteroendocrine cells while being safe with few side effects. The composition contains one or more of an Oldenlandia brachypoda extract, a Spergularia marina extract, a Disporum smilacinum extract, a Persicaria posumbu extract and a Geum aleppicum extract as an active ingredient. The composition of the present disclosure can be usefully used as a pharmaceutical composition or a food composition for preventing, improving or treating diabetes mellitus, improving or treating heart diseases, improving or treating arteriosclerosis, improving or treating digestive disorders and malabsorption, preventing or treating obesity or suppressing appetite, protecting nerves, treating or improving liver diseases, and so forth. In addition, the composition of the present disclosure can promote the secretion of GLP-1, CCK or 5-HT, affect the activation of hTGR5 and act as TRP, TRPA1, G protein and PLCβ2 agonists.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of stimulating secretion of glucagon-like peptide-1 (GLP-1) in a subject in need thereof, the method comprising: administering to the subject an effective amount of a composition comprising at least one of a Disporum smilacinum hydro-ethanolic extract, a Persicaria posumbu hydro-ethanolic extract and a Geum aleppicum hydro-ethanolic extract. 2. The method of claim 1 , wherein the subject is diagnosed with a disorder selected from the group consisting of: diabetes, obesity, a digestive disorder, gastrointestinal malabsorption, a liver disease, a heart disease and arteriosclerosis. 3. A method of stimulating secretion of cholecystokinin (CCK) in a subject in need of such stimulation, the method comprising: administering to the subject an effective amount of a composition comprising at least one of a Disporum smilacinum hydro-ethanolic extract, a Persicaria posumbu hydro-ethanolic extract and a Geum aleppicum hydro-ethanolic extract. 4. The method of claim 3 , wherein the subject is diagnosed with a disorder selected from the group consisting of: diabetes, obesity, a digestive disorder, gastrointestinal malabsorption, a liver disease, a heart disease and arteriosclerosis. 5. A method of stimulating secretion of 5-hydroxytryptamine (5-HT) in a subject in need of such stimulation, the method comprising: administering to the subject an effective amount of a composition comprising at least one of a Disporum smilacinum hydro-ethanolic extract, a Persicaria posumbu hydro-ethanolic extract and a Geum aleppicum hydro-ethanolic extract. 6. The method of claim 5 , wherein the subject is diagnosed with a disorder selected from the group consisting of: diabetes, obesity, a digestive disorder, gastrointestinal malabsorption, a liver disease, a heart disease and arteriosclerosis. 7. A method of activing hTGR5 (human TGR5 (G protein-coupled bile acid receptor 131, GPR131)) in a subject in need thereof, the method comprising: administering, to a subject, a composition comprising at least one of a Disporum smilacinum hydro-ethanolic extract, a Persicaria posumbu ethanolic hydro-ethanolic and a Geum aleppicum hydro-ethanolic extract. 8. The method of claim 7 , wherein the subject is diagnosed with a disorder selected from the group consisting of: diabetes, obesity, a digestive disorder, gastrointestinal malabsorption, a liver disease, a heart disease and arteriosclerosis.
Assignees
Inventors
Classifications
- A61K36/748Primary
Oldenlandia or Hedyotis · CPC title
Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn · CPC title
Plant extracts · CPC title
having effect on cardiovascular health · CPC title
having an effect on the health of the nervous system or on mental function · CPC title
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- What does patent US10293009B2 cover?
- The present disclosure relates to a pharmaceutical composition or a food composition which has excellent activity of stimulating enteroendocrine cells while being safe with few side effects. The composition contains one or more of an Oldenlandia brachypoda extract, a Spergularia marina extract, a Disporum smilacinum extract, a Persicaria posumbu extract and a Geum aleppicum extract as…
- Who is the assignee on this patent?
- Korea Food Res Inst
- What technology area does this patent fall under?
- Primary CPC classification A61K36/748. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 21 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).