Peg free stable low viscosity oil-in-water emulsion and use thereof

Patent metadata

Field	Value
Publication number	US-10292925-B2
Application number	US-201515549183-A
Country	US
Kind code	B2
Filing date	Mar 13, 2015
Priority date	Mar 13, 2015
Publication date	May 21, 2019
Grant date	May 21, 2019

Abstract

The present invention relates to a PEG free, stable, low viscosity classic oil-in-water emulsion and the use and preparation thereof. The oil-in-water emulsion comprises, A) a primary emulsifier selected from alkyl polyglucosides and long chained polyglycerol esters, B) a secondary emulsifier selected from short chained polyglycerol esters and short chained sorbitan esters, and optionally a thickener if the amount of secondary emulsifier is below 2.5 wt. %. The emulsion is a classic emulsion and can be sprayable. The emulsion is suitable to prepare spray or foam emulsion products with good application effect.

First claim

The invention claimed is:

1. An oil-in-water emulsion, comprising,
A) from 0.1 to 6 wt % based in the total weight of the oil-in-water emulsion of a primary emulsifier selected from the group consisting of
A1) alkyl polyglucosides with alkyl modifications out of the chemical class of linear or branched, saturated or unsaturated fatty alcohols with a chain length of C16 to C18 wherein the alkyl polyglucoside has a glucoside polymerization degree of from 1.0 to 1.7; and
A2) long chained polyglycerol esters with fatty acid moiety out of the chemical class of linear or branched, saturated or unsaturated fatty acids with a chain length of C16-C22; wherein the long chained polyglycerol ester has a glycerin polymerization degree of 5-12; wherein the molar ratio of polyglycerol moiety to fatty acid moiety is in the range of 0.3-2.5;
and
B) from 0.05 to less than 2.5 wt % based in the total weight of the oil-in-water emulsion of a secondary emulsifier selected from the group consisting of
B1) short chained polyglycerol esters prepared from linear or branched, saturated or unsaturated fatty acids with a chain length of C8-C12; wherein the short chained polyglycerol ester has a glycerin polymerization degree of 3-5; and wherein the molar ratio of polyglycerol moiety to fatty acid moiety is in the range of 0.2-2; and
B2) short chained sorbitan esters prepared from linear or branched, saturated or unsaturated fatty acids with a chain length of C8-C12; wherein the molar ratio of sorbitan moiety to fatty acid moiety is in the range of 0.2-2;
provided that the emulsion further comprises a thickener with an amount of ≥0.05 wt. %, based on the total weight of the oil-in-water emulsion
wherein the oil-in-water emulsion does not include C12-C24 alcohol and the viscosity of the oil-in-water emulsion is between 5 mPas and 1200 mPas, with the measurement using Brookfield RVT, SP04, 100 rpm.

2. The oil-in-water emulsion of claim 1 , wherein the viscosity of the oil-in-water emulsion is between 10 mPas and 1000 mPas, with the measurement using Brookfield RVT, SP04, 100 rpm.

3. The oil-in-water emulsion of claim 1 , wherein the mean droplet size of the oil-in-water emulsion is from 0.8 μm to 3 μm.

4. The oil-in-water emulsion of claim 1 , wherein the weight ratio of emulsifier/oil in the emulsion is ≤1/2.5.

5. The oil-in-water emulsion of claim 1 , wherein the emulsion is PEG free.

6. The oil-in-water emulsion of claim 1 , wherein the emulsion is sprayable.

7. The oil-in-water emulsion of claim 1 , wherein the emulsion comprises thickeners of from 0.07-0.10 wt. % of carbomer and from 0.01-0.05 wt. % of gellan gum, the wt % based on the total weight of the emulsion.

8. The oil-in-water emulsion of claim 1 , wherein the secondary emulsifier is selected from the group consisting of polyglyceryl-3 caprate, polyglyceryl-4 caprate, polyglyceryl-4 laurate, polyglyceryl-3 caprylate/caprate, sorbitan laurate, sorbitan sesquicaprylate, and any mixtures thereof.

9. A cosmetic, dermatological or pharmaceutical preparation, or cleaning preparation and/or care preparation for the household and industry, comprising the oil-in-water emulsion of claim 1 .

10. A cosmetic, dermatological or pharmaceutical product, or a cleaning product and/or care product for the household and industry, comprising the oil-in-water emulsion of claim 1 and a package.

11. The oil-in-water emulsion of claim 1 , wherein the long chained polyglycerol ester has a glycerin polymerization degree of 5-12; wherein the molar ratio of polyglycerol to fatty acid moiety is in the range of 0.4-2; and
B) a secondary emulsifier selected from the group consisting of
B1) short chained polyglycerol esters prepared from linear or branched,
saturated or unsaturated fatty acids with a chain length of C10-12; wherein the short chained polyglycerol ester has a glycerin polymerization degree of 3-5; wherein the molar ratio of polyglycerol moiety to fatty acid moiety is in the range of 0.3-1.8; and
B2) short chained sorbitan esters prepared from linear or branched, saturated or unsaturated fatty acids with a chain length of C10-12; wherein the molar ratio of sorbitan moiety to fatty acid moiety is in the range of 0.3-1.8,
wherein the oil-in-water emulsion does not include C12-C24 alcohol and the viscosity of the oil-in-water emulsion is between 5 mPas and 1000 mPas, with the measurement using Brookfield RVT, SP04, 100 rpm.

12. The oil-in-water emulsion of claim 11 , wherein the viscosity of the oil-in-water emulsion is between 10 mPas and 600 mPas, with the measurement using Brookfield RVT, SP04, 100 rpm.

13. The oil-in-water emulsion of claim 12 , wherein the mean droplet size of the oil-in-water emulsion is from 0.8 μm to 3 μm.

14. The oil-in-water emulsion of claim 11 , wherein the weight ratio of emulsifier/oil in the emulsion is less than 1/4.

15. The oil-in-water emulsion of claim 11 , wherein the weight ratio of emulsifier/oil in the emulsion is less than 1/5.

16. The oil-in-water emulsion of claim 11 , wherein the emulsion is PEG free.

17. The oil-in-water emulsion of claim 11 , wherein the emulsion is sprayable.

18. The oil-in-water emulsion of claim 11 , wherein the emulsion comprises thickeners of 0.07-0.10 wt. % of carbomer and 0.01-0.05 wt. % of gellan gum.

19. The oil-in-water emulsion of claim 11 , wherein the emulsion comprises thickeners of 0.02-0.1 wt. % of carbomer and 0.01-0.05 wt. % of gellan gum.

20. The oil-in-water emulsion of claim 11 , wherein the secondary emulsifier is selected from the group consisting of: polyglyceryl-3 caprate, polyglyceryl-4 caprate, polyglyceryl-4 laurate, polyglyceryl-3 caprylate/caprate, sorbitan laurate, sorbitan sesquicaprylate, and any mixtures thereof.

Assignees

• Evonik Specialty Chemicals Shanghai Co Ltd
• Evonik Degussa Gmbh

Inventors

• Gu Yinghua
• Zhang Haizhou
• Friedrich Achim
• Meyer Juergen
• Dahl Verena
• Chu Juan
• Von Hof Jan Marian

Classifications

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61K8/4973

  with oxygen as the only hetero atom · CPC title

• A61K9/107

  Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)} · CPC title

• A61K8/0208

  Tissues; Wipes; Patches · CPC title

• A61K2800/21

  Emulsions characterized by droplet sizes below 1 micron · CPC title