Device, apparatus and method for determining particle size distribution

Patent metadata

Field	Value
Publication number	US-10288542-B2
Application number	US-201615013529-A
Country	US
Kind code	B2
Filing date	Feb 2, 2016
Priority date	Feb 2, 2016
Publication date	May 14, 2019
Grant date	May 14, 2019

Abstract

An imaging device for determining particle size distribution including a sample receptacle containing a sample and an imager capable of capturing a plurality of images of the sample in a region of observation. The imaging device further includes a radiation source provided linearly opposite to the imager and a base platform that supports the imager and the radiation source.

First claim

The invention claimed is:

1. An apparatus for determining particle size distribution, the apparatus comprising:
an imaging device comprising an imager for capturing a plurality of images of a sample; and
a computing unit communicatively coupled to the imaging device, the computing unit comprising:
a processor comprising:
an analyzer configured to determine a first position at a first time instance and a second position at a second time instance of at least one particle of the sample within at least one portion of the plurality of images;
a prediction unit configured to predict a probable position of the at least one particle for the second time instance based on the first position of the at least one particle and a predetermined value, wherein the predetermined value is determined based on a gravitational force of particles of the sample, a dispersion medium viscosity of a dispersion medium in which the sample is added, a dispersion medium density of the dispersion medium in which the sample is added, or a combination thereof;
a comparator configured to calculate an actual velocity of the at least one particle based on the first position of the at least one particle at the first time instance and the second position of the at least one particle at the second time instance, and to calculate a probable velocity of the at least one particle based on the first position of the at least one particle at the first time instance and the probable position of the at least one particle at the second time instance;
a subtractor configured to determine a terminal velocity of particles of the sample in the at least one portion of the at least one image by calculating a difference between the actual velocity and the probable velocity; and
a calculator configured to determine the particle size distribution using the terminal velocity.

2. The apparatus of claim 1 , wherein the imaging device comprises:
a receptacle enclosure to hold a sample receptacle that contains the sample;
a base platform that supports the receptacle enclosure, the base platform having at least one leveler; and
a housing that encloses the base platform and the receptacle enclosure.

3. The apparatus of claim 2 , wherein the imaging device further comprises:
a guide mounted on the base platform; and
an image capture assembly mounted on the guide, the image capture assembly comprising the imager and a support.

4. The apparatus of claim 1 , wherein the imaging device further comprises:
a radiation source mounted on a base platform linearly opposite to the imager.

5. A method for determining particle size distribution comprising:
capturing a plurality of images of a sample contained in a sample receptacle with an imager;
determining a first position of at least one particle within at least one portion of the plurality of images at a first time instance;
determining a second position of the at least one particle within the at least one portion of the plurality of images at a second time instance;
predicting a probable position of the at least one particle based on the first position of the at least one particle and a predetermined value, wherein the predetermined value is determined based on a gravitational force of particles of the sample, a dispersion medium viscosity of a dispersion medium in which the sample is added, a dispersion medium density of the dispersion medium in which the sample is added, or a combination thereof;
calculating an actual velocity of the at least one particle based on the first position of the at least one particle at the first time instance and the second position of the at least one particle at the second time instance;
calculating a probable velocity of the at least one particle based on the first position the at least one particle at the first time instance and the probable position of the at least one particle at the second time instance;
determining a terminal velocity of particles of the sample in the at least one portion of the at least one image by calculating a difference between the actual velocity and the probable velocity; and
calculating the particle size distribution from the terminal velocity.

6. The method of claim 5 further comprising:
adjusting the sample receptacle perpendicular to ground level; and
adjusting position of the imager in line with a region of observation of the sample contained in the sample receptacle.

7. The method of claim 5 , wherein the sample comprises magnetized particles and non-magnetized particles suspended in the dispersion medium.

8. The method of claim 7 further comprising:
demagnetizing the sample placed in the sample receptacle; and
distributing an effect of the magnetized particles over the non-magnetized particles.

9. The apparatus of claim 1 , wherein the imaging device further comprises:
a sample receptacle containing a sample;
a radiation source provided linearly opposite to the imager; and
a base platform that supports the imager and the radiation source.

10. The apparatus of claim 9 , wherein the sample in the sample receptacle comprises an upper region, a middle region and a bottom region, wherein the middle region is the region of observation of the sample.

11. The apparatus of claim 9 , wherein the radiation source is configured to produce an electromagnetic beam of wavelength 620-780 nm.

12. The apparatus of claim 9 , wherein the base platform is provided with at least one leveler.

13. The apparatus of claim 9 , further comprising:
a guide mounted on the base platform; and
an image capture assembly mounted on the guide, the image capture assembly comprising the imager and a support.

14. The apparatus of claim 13 , wherein the support further comprises:
an upper mounting plate that receives the imager;
a vertical slide extending from the upper mounting plate towards the guide; and
a lower sliding plate that slides along an axis of the guide.

15. The apparatus of claim 13 , further comprising:
a receptacle enclosure to hold the sample receptacle that contains the sample; and
a housing that encloses the base platform, the receptacle housing, the guide and the image capture assembly.

16. The apparatus of claim 1 , wherein the imager is a complementary metal-oxide-semiconductor (CMOS) sensor.

Assignees

• Mishra Anant Kumar
• SSM Naveen Kumar
• Siemens Healthcare Diagnostics Inc

Inventors

• Mishra Anant Kumar
• SSM Naveen Kumar

Classifications

• G06K9/00134

  Physics · mapped topic

• G01N15/0227 Primary

  using imaging; using holography · CPC title

• G01N15/10

  Investigating individual particles · CPC title

• G01N15/02

  Investigating particle size or size distribution (by measuring osmotic pressure G01N7/10; investigating sedimentation of particle suspensions G01N15/04; investigating individual particles G01N15/10) · CPC title

• G01N15/04

  Investigating sedimentation of particle suspensions · CPC title