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Self-assembled beta solenoid protein scaffolds
US10287332B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10287332-B2 |
| Application number | US-201515111687-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 26, 2015 |
| Priority date | Jan 24, 2014 |
| Publication date | May 14, 2019 |
| Grant date | May 14, 2019 |
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- Title
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- Abstract
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Abstract
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The present invention provides amyloid fibrils comprising a plurality of modified β solenoid protein (mBSP) monomers. The mBSP monomers are modified to enhance self-assembly and are useful in a variety of applications.
First claim
Opening claim text (preview).
What is claimed is: 1. An amyloid fibril comprising a plurality of modified β solenoid protein (mBSP) monomers, wherein each mBSP monomer is modified from a non-amyloidogenic wild-type β solenoid protein (WT-BSP) to remove an end cap that prevents amyloid aggregation and thereby allow for controlled amyloid self-assembly. 2. The amyloid fibril of claim 1 , wherein the mBSP monomers are derived from an antifreeze protein. 3. The amyloid fibril of claim 2 , wherein the antifreeze protein is a spruce budworm antifreeze protein. 4. The amyloid fibril of claim 3 , wherein the mBSP has the sequence shown in SEQ ID NO: 1. 5. The amyloid fibril of claim 1 , wherein the antifreeze protein is a rye grass antifreeze protein. 6. The amyloid fibril of claim 5 , wherein the mBSP has the sequence shown in SEQ ID NO: 2. 7. The amyloid fibril of claim 1 , that is modified to include at least one amino acid residue that promotes attachment of the fibril to a solid support, a nanoparticle, a biological molecule, or a second amyloid fibril.
Assignees
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Classifications
from mammals · CPC title
from plants · CPC title
- C07K14/43563Primary
from insects · CPC title
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Frequently asked questions
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- What does patent US10287332B2 cover?
- The present invention provides amyloid fibrils comprising a plurality of modified β solenoid protein (mBSP) monomers. The mBSP monomers are modified to enhance self-assembly and are useful in a variety of applications.
- Who is the assignee on this patent?
- Univ California
- What technology area does this patent fall under?
- Primary CPC classification C07K14/43563. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).